| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | BEFREE | BARD1 Cys557Ser was associated with an increased BC risk (P = 0.04, OR = 3.4 [95 % CI 1.2-10.2]) among cases belonging to families with a strong family history of BC. | 22544576 | 2012 |
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|
0.080 | GeneticVariation | BEFREE | The BARD1 Cys557Ser variant was not significantly associated with risk of breast cancer from single SNP analysis, with a pooled effect estimate of 0.90 (95% CI: 0.71-1.15) in BRCA1 carriers and 0.87 (95% CI: 0.59-1.29) in BRCA2 carriers. | 21393566 | 2011 |
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|
0.080 | GeneticVariation | BEFREE | This meta-analysis strongly suggests that BARD1 Cys557Ser mutation is not associated with increased breast cancer risk. | 21809034 | 2011 |
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|
0.080 | GeneticVariation | BEFREE | We conclude that the BARD1 Cys557Ser variant is not associated with breast cancer risk. | 18481171 | 2009 |
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|
0.080 | GeneticVariation | BEFREE | There was no clear association between the presence of the BARD1 Cys557Ser allele and breast cancer in Poland. | 17333333 | 2008 |
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|
0.080 | GeneticVariation | BEFREE | These results provide further evidence that BARD1 Cys557Ser confers a slightly increased risk of breast cancer in women. | 16825437 | 2006 |
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|
0.080 | GeneticVariation | BEFREE | These results suggest that the contribution of the BARD1 germline variants to breast cancer predisposition is very limited, and that neither Cys557Ser nor Val507Met have an effect on familial breast cancer susceptibility. | 16333312 | 2006 |
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|
0.080 | GeneticVariation | BEFREE | Lobular and medullary breast carcinomas were overrepresented amongst Cys557Ser carriers. | 16768547 | 2006 |