DisGeNET - a database of gene-disease associations

Breast Carcinoma, C0678222

Variant: rs2981579 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs2981579

FGFR2

0.740

GeneticVariation

BEFREE

This meta-analysis of case-control studies provides strong evidence that fibroblast growth factor 2 (FGFR2; rs11200014, rs2981579, and rs1219648) polymorphisms are significantly associated with the BC risk.

29390357

2017

dbSNP:

rs2981579

FGFR2

0.740

GeneticVariation

GWASCAT

Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.

27354352

2016

dbSNP:

rs2981579

FGFR2

0.740

GeneticVariation

GWASCAT

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.

25751625

2015

dbSNP:

rs2981579

FGFR2

0.740

GeneticVariation

GWASCAT

Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

23535729

2013

dbSNP:

rs2981579

FGFR2

0.740

GeneticVariation

BEFREE

Four SNPs mapped to 10q26.13/FGFR2 were associated with increased breast cancer risk via an additive model with per-allelic risks (95 % CI) of 1.26 (1.12-1.43) at rs1219648, 1.22 (1.07-1.38) at rs2981582, 1.21 (1.07-1.36) at rs2981579, and 1.18 (1.04-1.35) at rs11200014.

22965832

2012

dbSNP:

rs2981579

FGFR2

0.740

GeneticVariation

BEFREE

A dose-dependent association was observed between the risk of breast cancer and the genetic risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936.

22160591

2012

dbSNP:

rs2981579

FGFR2

0.740

GeneticVariation

BEFREE

Results from the current meta-analysis indicates that three novel functional polymorphisms (rs11200014, rs2981579, and rs2981578) in the promoter of FGFR2 gene are associated with breast cancer susceptibility and might be a potential biomarkers for breast cancer risk.

23124475

2012

dbSNP:

rs2981579

FGFR2

0.740

GeneticVariation

GWASCAT

Genome-wide association study identifies five new breast cancer susceptibility loci.

20453838

2010

dbSNP: