Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4415084
rs4415084
0.790 GeneticVariation BEFREE Application of our method to a breast cancer susceptibility region in 5p12 demonstrates that the risk allele rs4415084-T correlates with higher expression levels of the protein-coding gene mitochondrial ribosomal protein S30 (<i>MRPS30</i>) and lncRNA <i>RP11-53O19.1</i> We propose an intergenic SNP rs4321755, in linkage disequilibrium (LD) with the GWAS SNP rs4415084 (<i>r</i><sup>2</sup> = 0.988), to be the predicted functional SNP. 29351903

2018

dbSNP: rs4415084
rs4415084
0.790 GeneticVariation BEFREE This study aims to determine the association between FGF10 (rs4415084 C>T), FGFR2 (rs2981582 C>T) and MAP3K1 (rs889312 A>C) gene polymorphisms and breast cancer, to analyse the discriminative ability of each SNP and to test the accuracy of the predictive breast cancer risk model which includes all SNPs. 29372690

2017

dbSNP: rs4415084
rs4415084
0.790 GeneticVariation BEFREE Significant associations with breast cancer were observed for rs13387042 and rs4415084 with OR (95% CI) per-allele 1.29 (1.00-1.66) and 0.83 (0.71-0.97), respectively. 27022606

2016

dbSNP: rs4415084
rs4415084
0.790 GeneticVariation BEFREE After that, a number of studies reported that the rs10941679, rs4415084, and rs981782 polymorphism in chromosome 5p12 has been implicated in BC risk. 23977236

2013

dbSNP: rs4415084
rs4415084
0.790 GeneticVariation BEFREE Our findings demonstrated that rs10941679-G allele and rs4415084-T allele might be risk-conferring factors for the development of breast cancer, especially in Caucasians and East-Asians. 24039999

2013

dbSNP: rs4415084
rs4415084
0.790 GeneticVariation BEFREE A genome-wide association study, conducted among women of European ancestry, has identified two single-nucleotide polymorphisms (SNPs) rs4415084 (T>C) and rs10941679 (A>G) at chromosome 5p12 were associated with risk of breast cancer, suggesting that genetic variants in this region may have a role in the development of breast cancer. 22832384

2012

dbSNP: rs4415084
rs4415084
T 0.790 GeneticVariation GWASCAT Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. 21263130

2011

dbSNP: rs4415084
rs4415084
0.790 GeneticVariation BEFREE In exploratory analyses, we found that the radiation-associated breast cancer risk varied significantly by linked markers in 5p12 (rs930395, rs10941679, rs2067980 and rs4415084) in the mitochondrial ribosomal protein S30 (MRPS30) gene (P(interaction) = 0.04). 20095854

2010

dbSNP: rs4415084
rs4415084
0.790 GeneticVariation BEFREE We confirmed the reported association of rs4415084 SNP with overall risk of breast cancer (P = 0.06), and, as in the original study, observed a stronger association with estrogen receptor positive tumors (P = 0.03). 20140701

2010

dbSNP: rs4415084
rs4415084
0.790 GeneticVariation BEFREE We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 x 10(-12) for rs10941679). 18438407

2008