Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.090 | GeneticVariation | BEFREE | The present study indicates that CYP19 rs464</span>6 polymorphism is related to DFS in early breast cancer and that the prognosis index of the homozygous for the minor allele (AA) may depend on menopause status. | 25793413 | 2015 |
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0.090 | GeneticVariation | BEFREE | These findings suggest that the presence of the rs4646 variant may be a predictive factor of the benefit of AI treatment for BC. | 26067721 | 2015 |
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0.090 | GeneticVariation | BEFREE | The homozygous minor allele (AA) of CYP19A1 rs4646 is significantly associated with improved clinical outcome of hormone therapy in premenopausal HR-positive early breast cancer patients, but with a worse impact on postmenopausal women. | 26191232 | 2015 |
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0.090 | GeneticVariation | BEFREE | The common allele of rs4646, which has been associated with increased breast cancer risk, was associated with low-histological grade and small tumour size (P = 0.001 and 0.015; 1-sided, respectively). | 20960227 | 2011 |
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0.090 | GeneticVariation | BEFREE | Testing for the rs4646 polymorphism could be a useful tool in order to orientate the treatment in elderly BC patients. | 20144226 | 2010 |
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0.090 | GeneticVariation | BEFREE | A common haplotype composed of the Val(80) G allele and three haplotype-tagging single nucleotide polymorphisms (rs727479, rs10046, and rs4646) in the CYP19 coding region showed a trend to association with breast cancer risk in BRCA1 carriers ages <50 years. | 19366906 | 2009 |
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0.090 | GeneticVariation | BEFREE | Testing for the CYP19 rs4646 SNP as a predictive tool for breast cancer patients on antiaromatase therapy deserves prospective evaluation. | 18245543 | 2008 |
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0.090 | GeneticVariation | BEFREE | In a case-control study nested within a breast self-examination trial conducted in China, we examined whether CYP19A1 polymorphisms (rs1870049, rs1004982, rs28566535, rs936306, rs11636639, rs767199, rs4775936, rs11575899, rs10046, and rs4646) were associated with risk of breast cancer and fibrocystic breast conditions. | 19064562 | 2008 |
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0.090 | GeneticVariation | BEFREE | SNPs rs10046 and rs4646 may influence the HER2 status of breast cancer tumors, and rs10046 genotypes are associated with an altered DFS. | 18049890 | 2008 |