|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no association between rs4680 and rs1056836 genotypes and adduct ratios or breast cancer status.
|
30525503 |
2019 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotype was carried out for 5 single nucleotide polymorphisms (rs4646903, rs1056836, rs1695, rs4970737, and rs4680) using direct sequencing.The polymorphic genotypes of glutathione S-transferase (GSTP1) (P = .044) and catechol-O-methyltransferase (COMT) (P = .008) showed significantly different distributions, while that of cytochrome P450 (CYP1B1) (P = .051) showed a slight difference in distribution between healthy women and patients with breast cancer.
|
30461653 |
2018 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
When assessing the independent effect of the COMT Val158Met polymorphism, we observed reduced risk for breast cancer amongst hormone replacement therapy using women who were homozygous carriers of the variant allele compared with those carrying the wild-type variant (RR = 0.41; 95% CI: 0.29-0.89).
|
23869875 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that the COMT Val158Met polymorphism is not a risk factor for breast cancer development.
|
24146281 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms CYP1A1 rs1048943, CYP1B1 rs1056836, COMT rs4680, GSTP1 rs1695, GSTT1 null and GSTM1 null which are involved in estrogen metabolism pathway.
|
23000097 |
2013 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis results suggest that the COMT Val158Met polymorphism may not contribute to breast cancer susceptibility.
|
23039364 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis indicates that COMT Val158Met polymorphism may be associated with decreased breast cancer</span> risk in Caucasian population.
|
22297695 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors.
|
21974969 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors.
|
21898113 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs (HSD17B1 (rs2010750, rs598126 and rs676387), COMT (rs4680), UGT1A1 (rs8175347) and ESR1 (rs9340799)) seemed to be related to MD in the same direction of their associations with breast cancer risk.
|
22199302 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found.
|
20878621 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control study was conducted to assess the associations between soy isoflavone intake and the CYP1A1 Ile462Val, CYP1B1 Val432Leu, and COMT Val158Met polymorphisms and breast cancer, as well as their combined effects on breast cancer.
|
21438753 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, COMT Val158Met polymorphism may be a low-penetrant risk factor for breast cancer development in European population.
|
20130981 |
2010 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conducted a large population-based case control study in Massachusetts, New Hampshire, and Wisconsin to examine six strategically selected COMT haplotype-tagging (ht) single nucleotide polymorphism (SNPs), including the val158met polymorphism (rs4680), in relation to breast cancer risk.
|
20150638 |
2010 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphism Val158Met of catechol-O-methyltransferase (COMT) may contribute to estrogen-induced carcinogenesis of breast cancer.
|
20591221 |
2010 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
COMT rs4680 genotypes did not have a modifying effect on the association of green tea intake with breast cancer risk.
|
19074205 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although CYP1B1 and COMT genotypes did not exhibit statistically significant association with breast cancer risks when analyzed individually, COMT wild type (Val(158)Val) in combination with CYP1B1 heterozygous variant (Leu(432)Val) [OR: 0.21; 95% CI (0.05-0.82), p value; 0.021] and COMT heterozygous variant (Val(158)Met) in combination with CYP1B1 wild type (Leu(432)Leu) [OR: 0.29; 95% CI (0.08-0.96), p value; 0.042] showed significant protective association with premenopausal breast cancer risk.
|
20037207 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the CYP1A1 gene may be genetic markers for breast cancer prognosis in Chinese women.
|
17429315 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study we evaluated the association between the interleukin-1B C-31T, catechol-O-methyltransferase Val158Met, and thymidylate synthase (TS) 1494del6 polymorphisms and breast cancer.
|
17385677 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
When stratified by menopausal status, COMT Val158Met L/L (OR: 11.94; 95% CI: 1.48-96.03, P=0.02) and ERalpha PvuII P/p genotypes (OR: 2.67; 95% CI: 1.01-7.05, P=0.048) were associated with a significantly elevated risk of breast cancer in premenopausal women, and there was a association between ERalpha XbaI x/x genotype and the nonsignificantly increased risk of breast cancer in premenopausal women (OR: 6.88; 95% CI: 0.80-59.15, P=0.079).
|
17562079 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional Val158Met polymorphism in the COMT gene has been known as a susceptible marker for breast cancer.
|
17047485 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we evaluated the frequency of different polymorphisms related with estrogen metabolism [COMT Val158Met, CYP17 (5'UTR, T27C); HSD17beta1 Gly313Ser and MnSOD Val16Ala] in a breast cancer resistant population, the Xavante Indians, and the frequencies were compared with the ones reported in other populations where breast cancer case-control studies dealing with these polymorphisms have been carried out.
|
16969494 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotypes in another LD block, which included COMT Val(158)Met, were not associated with breast cancer risk (global P = 0.76).
|
17018638 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferase COMT-L (V158M) genotypes, the risk for developing breast cancer was significantly increased in patients with a body mass index (BMI) greater than 24 kg m(-2) (OR: 1.42 (95%CI=1.04-1.93)).
|
15386537 |
2005 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the associations between breast cancer and sequence variants in several genes in the estradiol/estrone metabolism pathway (CYP1A1*2A, CYP1A2*1F, CYP1B1 Leu432Val, CYP3A4*1B, COMT Val158Met, SULT1A1Arg213His) as well as the Arg554Lys variant in AHR (a transcription factor for CYP1A1, CYP1A2, and CYP1B1) in a case-control study of 1,339 breast cancer cases and 1,370 controls nested in the Multiethnic Cohort Study.
|
16103451 |
2005 |