Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4784227
rs4784227
0.770 GeneticVariation BEFREE Results showed that in northwest Chinese Han population, SNP rs17530068 (LOC105377871) increases the risk of breast cancer and SNP rs4784227 (CASC16) promotes lymph node metastasis in breast cancer patients. 31655495

2020

dbSNP: rs4784227
rs4784227
T 0.770 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2017

dbSNP: rs4784227
rs4784227
0.770 GeneticVariation GWASCAT Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. 27117709

2016

dbSNP: rs4784227
rs4784227
0.770 GeneticVariation BEFREE Five of the 17 SNPs were significantly associated (P ≤ 0.05) with overall breast cancer in the same direction as previously reported: rs13387042 (2q35/TNP1), rs4973768 (3p24/SLC4A7), rs2046210 (6q25/ESR1), rs1219648 (10q26/FGFR2), and rs4784227 (16q12/TOX3). 24510657

2015

dbSNP: rs4784227
rs4784227
0.770 GeneticVariation BEFREE ABC successfully identifies previously characterized functional SNVs, such as the rs4784227 breast cancer risk associated SNP that modulates the affinity of FOXA1 for the chromatin. 25995231

2015

dbSNP: rs4784227
rs4784227
T 0.770 GeneticVariation GWASCAT Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25. 25327703

2014

dbSNP: rs4784227
rs4784227
0.770 GeneticVariation BEFREE Significant associations with breast cancer risk were observed for rs4784227 and rs8051542 with odds ratios (OR) of 1.31 ((95% confidence intervals (CI), 1.10-1.57)) and 1.26 (95% CI, 1.02-1.56), respectively, per T allele. 24481062

2014

dbSNP: rs4784227
rs4784227
0.770 GeneticVariation BEFREE The results indicated that both polymorphisms were significantly associated with the risk of breast cancer, with per allele OR = 1.35, (95%CI = 1.17-1.57) for rs2046210 and per allele OR = 1.24 (95%CI = 1.06-1.45) for rs4784227. 25531440

2014

dbSNP: rs4784227
rs4784227
0.770 GeneticVariation BEFREE In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 (rs7716600), 6q25.1/ESR1 (rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/FGFR2 (rs10736303), and 16q12.1/TOX3 (rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (Ptrend < 0.05). 22452962

2012

dbSNP: rs4784227
rs4784227
T 0.770 GeneticVariation GWASCAT SNP rs4784227 is located at 16q12.1, a region identified previously for breast cancer risk among Europeans. 20585626

2010

dbSNP: rs4784227
rs4784227
0.770 GeneticVariation BEFREE These results provide strong evidence implicating rs4784227 as a functional causal variant for breast cancer in the locus 16q12.1 and demonstrate the utility of conducting genetic association studies in populations with different genetic architectures. 20585626

2010