|
rs743572
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Further stratification analysis by clinical characteristics showed rs743572 was associated with estrogen receptor status (heterozygote model: OR=2.13, 95% CI=1.47-3.08; homozygote model: OR=3.29, 95% CI=1.94-5.58; dominant model: OR=2.39, 95% CI=1.69-3.37) and progesterone receptor status (homozygote model: OR=3.17, 95% CI=1.82-5.55), but there was no association between rs2486758 and clinical characteristics of BC.
|
30013390 |
2018 |
|
rs743572
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In conclusion, rs743572 may increase breast cancer risk in postmenopausal individuals, but not in premenopausal folks and general populations.
|
29423115 |
2018 |
|
rs743572
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The purpose of the current study was to analyze the association between CYP17A1 T27C (rs743572) and LEP -2548G>A (rs7799039) gene polymorphisms and breast cancer.
|
26407154 |
2015 |
|
rs743572
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We examined the association of single nucleotide polymorphism (SNP) in estrogen receptors, ESR1 (rs2234693) and ESR2 (rs2987983); estrogen biosynthesis enzymes, CYP17A1 (rs743572); and aromatase, CYP19A1 (rs700519) with breast cancer risk.
|
24430361 |
2014 |
|
rs743572
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We detected SNP-HT interactions in women overall within CYP1B1 (rs1800440; p (het) = 0.003) and within CYP17A1 (rs743572; p (het) = 0.009) in which never users of HT were at a decreased risk of breast cancer, while ever users were at a non-significant increased risk.
|
22418777 |
2012 |
|
rs743572
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A polymorphism (-34 T > C; rs743572) in the cytochrome P450c17alpha gene (CYP17A1) encoding an enzyme which controls estrogen levels was reportedly associated with breast cancer risk in average risk populations.
|
20798986 |
2011 |
|
rs743572
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In this study, we genotyped polymorphisms in the regulatory regions of ER-alpha (rs3798577) and other two estrogen-metabolizing enzyme genes CYP17 (rs743572) and CYP19 (rs10046) among 300 breast cancer cases and 390 controls in a Chinese population.
|
18629629 |
2009 |
|
rs743572
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In addition, a stratified analysis by menopausal status indicated that the association of the CYP1A2 (rs762551) and CYP17 (rs743572) polymorphisms with breast cancer risk were mainly evident in premenopausal, while ERRG (rs1857407) was significant in postmenopausal women.
|
19415745 |
2009 |
|
rs743572
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In a case-control study of Chinese women, we examined genotypes of the CYP11A1 pentanucleotide [(TAAAA)n] repeat (D15S520), CYP17A1 rs743572, and HSD17B1 rs605059 polymorphisms in relation to the risk of breast cancer and fibrocystic breast conditions, comparing 615 women with breast cancer and 467 women with fibrocystic breast conditions separately with 879 women without clinical breast disease.
|
18483327 |
2008 |