|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HER2 Ile655Val polymorphism is negatively associated with breast cancer susceptibility.
|
29417620 |
2018 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the HER2 codon 655 (rs1136201) polymorphism in 80 Austrian patients with BC and 100 healthy volunteers by pyrosequencing and polymerase chain reaction.
|
26504013 |
2015 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the HER2 codon 655 (rs1136201) polymorphism in 80 Austrian patients with BC and 100 healthy volunteers by pyrosequencing and polymerase chain reaction.
|
26637882 |
2015 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HER2 Ile655Val polymorphism was determined in 4167 patients with primary breast cancer using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.
|
24608202 |
2014 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, our meta-analysis findings suggest that the HER2 Ile655Val polymorphism is marginally associated with breast cancer susceptibility in worldwide populations with additive and dominant models, but not a recessive model.
|
25520082 |
2014 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this case control study we aimed to analyze the frequency of HER1 R497K (rs 11543848) and HER2 I655V (rs 1136201) Polymorphisms in breast cancer.
|
23594562 |
2013 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Analysis on clinico-pathological parameters showed neither HER2 Ile655Val nor PTEN IVS4 genotypes were not associated with any of the variables (p > 0.05).In conclusion, our findings suggest that the Ile/Val genotype of HER2 and ATCTT insertion (+/+) genotype of PTEN IVS4 gene may play an important role as genetic markers for breast cancer risk, but both genes genotypes may not be useful for predicting tumor prognosis in Turkish population.
|
23086302 |
2013 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis aimed to assess the association between ERBB2 Ile655Val and Ala1170Pro polymorphisms and the susceptibility to breast cancer.
|
23900832 |
2013 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One single-nucleotide polymorphism at codon 655 indicates a guanine-to-adenine substitution (Ile655Val) in the transmembrane domain-coding region of the HER-2/neu gene reported to be associated with increased risk of breast cancer.
|
21204706 |
2011 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It is unlikely that HER2 rs1136201 is a risk factor for breast cancer.
|
21474413 |
2011 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study was conducted to clarify the diagnostic and prognostic significance of TNF-alpha and its combination with HER-2 Ile655Val SNP in breast cancer.
|
20872355 |
2011 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The P53 gene codon 72 Arg/Pro and Her2 gene Ile655Val polymorphisms were not associated with the risk of breast cancer in Turkish women.
|
20380571 |
2010 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis suggests that HER2 Ile 655Val polymorphism may contribute to breast cancer risk.
|
20401632 |
2010 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In our study, we analyzed three polymorphisms in the HER2 gene: the single-nucleotide polymorphism (SNP) HER2 Ile(655)Val as well as another SNP (rs903506) close to it and a new screened dinucleotide repeat H(AC)I4 in intron 4, in a sample of 148 cases and 290 controls from the Tunisian population and investigated their association with breast cancer risk.
|
19929405 |
2010 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, they provide clinical evidence that HER-2 Ile655Val SNP does affect serum HER-2 levels and it can be regarded as a predictive biomarker for breast cancer patients with poor prognosis.
|
18237248 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of HER-2/neu Ile655Val polymorphism and the risk of breast cancer was borderline significant with the heterozygous carrier being at higher risk.
|
18837888 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study we aimed to determine whether the risk of breast cancer is associated with the I655V polymorphism of HER2 transmembrane domain-coding region at codon 655.
|
18721072 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study was conducted to clarify the predictive and prognostic significance of serum TGF-I(2)1 in breast cancer in relation to Ile655Val single nucleotide polymorphism (SNP) of human epidermal growth factor receptor-2 (HER-2).
|
18348656 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These study results suggest that Ile655Val polymorphism of the ERBB2 gene do not alter its activity and may not be associated with increased breast cancer risk among Chinese women.
|
17687647 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control study of the HER2 Ile655Val polymorphism and risk of breast cancer in Taiwan.
|
18062925 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of HER2 Ile655Val and cyclin D1 (CCND1) G870A are not associated with breast cancer risk but polymorphic allele of HER2 is associated with nodal metastases.
|
18237245 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on the association between the Ile to Val polymorphism at codon 655 of the human epithelial growth factor receptor 2 (HER-2) gene and susceptibility to breast cancer have been reported for almost all ethnic populations, with both positive or negative conclusions.
|
18090908 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Polymorphisms (SNP's) in GSTM1 (Present/Null); GSTP1 (Ile105Val), p53 (Arg72Pro), TGFbeta1 (Leu10Pro), c-erbB2 (Ile655Val), and GSTT1 (Null/Present) in breast cancer.
|
18058229 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Human ERBB2 presents several SNPs.One of these, Ile655Val, introduces a structural change in the transmembrane region of ERBB2 and has been the focus of debate over its potential role as a susceptibility marker for breast cancer risk.
|
17452776 |
2007 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study proposes the allelic imbalance of Ile655Val polymorphism between Greek Christian and Greek Muslim populations of Thrace contributes to the inconsistent association between this SNP and breast cancer risk across these two different ethnic groups.
|
17918664 |
2007 |