|
rs121434592
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The results obtained in this study suggest that Akti-1/2 might be a better inhibitor for the treatment of BC caused by the E17K mutation in AKT1.
|
31698236 |
2019 |
|
rs121434592
|
|
|
0.060 |
GeneticVariation |
BEFREE |
AKT1 mutations (E17K) have been found in 1.4-8% of breast cancer patients.
|
29086897 |
2018 |
|
rs121434592
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The data suggest that AKT1 (E17K) is the most likely disease driver in certain breast cancer patients.
|
27515171 |
2016 |
|
rs121434592
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Analysis of TCGA breast cancer data revealed that the mRNA expression, total protein levels, and phosphorylation of various RTKs are decreased in human tumors harboring AKT1(E17K).
|
27004402 |
2016 |
|
rs121434592
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Both AKT inhibitors caused highly significant growth inhibition of breast cancer explant models with AKT1(E17K) mutation.
|
26351323 |
2015 |
|
rs121434592
|
|
|
0.060 |
GeneticVariation |
BEFREE |
AKT1 E17K is a bona fide oncogene in a human luminal breast cancer context.
|
23888070 |
2013 |
|
rs2494740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three genetic variants (<i>AKT1</i> rs2494740, <i>AKT1</i> rs2494744, and <i>AKT1</i> rs2498789) and two lifestyle factors [body mass index (BMI) and dietary alcohol intake] as the top five most influential predictors for breast cancer risk.
|
29074537 |
2018 |
|
rs2494744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three genetic variants (<i>AKT1</i> rs2494740, <i>AKT1</i> rs2494744, and <i>AKT1</i> rs2498789) and two lifestyle factors [body mass index (BMI) and dietary alcohol intake] as the top five most influential predictors for breast cancer risk.
|
29074537 |
2018 |
|
rs2498789
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three genetic variants (<i>AKT1</i> rs2494740, <i>AKT1</i> rs2494744, and <i>AKT1</i> rs2498789) and two lifestyle factors [body mass index (BMI) and dietary alcohol intake] as the top five most influential predictors for breast cancer risk.
|
29074537 |
2018 |
|
rs3730358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP AKT1 (rs3730358) was suggested to modify the risk of breast cancer.
|
29202330 |
2018 |
|
rs3803304
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Despite the small sample size, we found that the intronic variant, AKT1 rs3803304, may act as a predictive biomarker in the risk of developing breast cancer in the high altitude Ecuadorian mestizo population.
|
30065942 |
2018 |
|
rs2494752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Epidemiologic studies suggested that mutations of the PI3K/PTEN/AKT pathway genes are associated with cancer risk, yet no data are available for PTEN rs701848, PIK3CA rs2699887, and AKT1 rs2494752 polymorphism and breast cancer(BC) risk.
|
28423632 |
2017 |