rs121913530
|
|
|
0.880 |
GeneticVariation |
UNIPROT |
|
|
|
rs121913530
|
|
A |
0.880 |
CausalMutation |
CLINVAR |
|
|
|
rs121909071
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
|
|
|
rs34424986
|
|
A |
0.720 |
CausalMutation |
CLINVAR |
|
|
|
rs104894360
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs121913281
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs121917901
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs121917902
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1324578301
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
rs17851045
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
rs180177042
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1805076
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs2071460
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
rs372594677
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
rs373227647
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs376526037
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs387906660
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs387906661
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs397507466
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs397516895
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs540635787
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs587782705
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs28934576
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results show: (1) wild-type p53 stimulates the transcription of reporter genes with p53CON and RGC in their 5' region while most p53 mutants occurring in human cancers have lost this activity; (2) the R273H mutant retains transcriptional activity for the p53CON sequence but not RGC; (3) some mutants are temperature-sensitive for the transcriptional activity with the p53CON but not the RGC sequence; (4) p53 mutants vary in their ability to inhibit wild-type p53 transactivation but there is no difference between p53CON and RGC sequences; (5) lung cancer cells with endogenous mutant p53 proteins (M246I in H23 cells and R248L in H322 cells) retain transcriptional activity for the p53CON but not the RGC sequence.
|
8336941 |
1993 |
rs11540652
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results show: (1) wild-type p53 stimulates the transcription of reporter genes with p53CON and RGC in their 5' region while most p53 mutants occurring in human cancers have lost this activity; (2) the R273H mutant retains transcriptional activity for the p53CON sequence but not RGC; (3) some mutants are temperature-sensitive for the transcriptional activity with the p53CON but not the RGC sequence; (4) p53 mutants vary in their ability to inhibit wild-type p53 transactivation but there is no difference between p53CON and RGC sequences; (5) lung cancer cells with endogenous mutant p53 proteins (M246I in H23 cells and R248L in H322 cells) retain transcriptional activity for the p53CON but not the RGC sequence.
|
8336941 |
1993 |
rs1019340046
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results show: (1) wild-type p53 stimulates the transcription of reporter genes with p53CON and RGC in their 5' region while most p53 mutants occurring in human cancers have lost this activity; (2) the R273H mutant retains transcriptional activity for the p53CON sequence but not RGC; (3) some mutants are temperature-sensitive for the transcriptional activity with the p53CON but not the RGC sequence; (4) p53 mutants vary in their ability to inhibit wild-type p53 transactivation but there is no difference between p53CON and RGC sequences; (5) lung cancer cells with endogenous mutant p53 proteins (M246I in H23 cells and R248L in H322 cells) retain transcriptional activity for the p53CON but not the RGC sequence.
|
8336941 |
1993 |