rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
Mutations of the BRAF gene in human cancer.
|
12068308 |
2002 |
rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.
|
22608338 |
2012 |
rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
|
19238210 |
2009 |
rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
Missense mutations of the BRAF gene in human lung adenocarcinoma.
|
12460919 |
2002 |
rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer.
|
23833300 |
2013 |
rs113488022
|
|
|
0.750 |
GeneticVariation |
BEFREE |
BRAF V600E is an emerging drug target in lung cancer, but the clinical significance of non-V600 BRAF mutations in lung cancer and other malignancies is less clear.
|
24035431 |
2013 |
rs113488022
|
|
|
0.750 |
GeneticVariation |
BEFREE |
The incidence of BRAF mutations other than V600E is significantly higher in lung cancer than in melanoma.
|
21483012 |
2011 |
rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
The incidence of BRAF mutations other than V600E is significantly higher in lung cancer than in melanoma.
|
21483012 |
2011 |
rs113488022
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Success of this design of clinical trials and practice was first demonstrated in EGFR inhibitor trials in lung cancer and has since been incorporated into subsequent targeted therapy trials including ALK-, ROS1-, and BRAF V600E-targeted therapies.
|
28786099 |
2017 |
rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer.
|
23524406 |
2013 |
rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
Genetic predictors of MEK dependence in non-small cell lung cancer.
|
19010912 |
2008 |
rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib.
|
22649091 |
2012 |
rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib.
|
22743296 |
2012 |
rs113488022
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Accordingly, the combination of MEK inhibitor with EGFR inhibitor was effective at shrinking tumors in mouse model of BRAF non-V600E mutant lung cancer.
|
29348459 |
2018 |
rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
BRAF and RAS mutations in human lung cancer and melanoma.
|
12460918 |
2002 |
rs113488022
|
|
T |
0.750 |
CausalMutation |
CLINVAR |
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
|
22773810 |
2012 |
rs113488022
|
|
|
0.750 |
GeneticVariation |
BEFREE |
V599E BRAF mutation was uncommon in Japanese lung cancer.
|
16376942 |
2006 |