rs2293347
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Compared with the rs2293347 GG genotype, the AA/AG genotypes were associated with a significantly decreased risk of lung cancer (adjusted OR = 0.28, 95% confidence interval [CI]=0.13-0.61, P<0.01).
|
31518089 |
2019 |
rs748491031
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology.
|
31207149 |
2019 |
rs884225
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis of rs2233947 and rs884225 showed that the AA haplotype was associated with a significantly decreased risk of lung cancer (P<0.01).
|
31518089 |
2019 |
rs11543848
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, no association was detected between rs712830, rs2072454, and rs11543848 SNPs and lung cancer risk.
|
30011810 |
2018 |
rs148934350
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several reports show that germline mutations in the kinase domain of epidermal growth factor receptor (<i>EGFR</i>) such as R776G, R776H, T790M, V843I and P848L, predispose to develop lung cancer.
|
30225213 |
2018 |
rs2072454
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, <i>EGFR</i> rs712829, rs2072454 SNPs, and TCCG haplotypes are associated with a risk of lung cancer among Jordanians.
|
30011810 |
2018 |
rs712829
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, <i>EGFR</i> rs712829, rs2072454 SNPs, and TCCG haplotypes are associated with a risk of lung cancer among Jordanians.
|
30011810 |
2018 |
rs1057519861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer.
|
27913578 |
2017 |
rs121913465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
S768I Mutation in EGFR in Patients with Lung Cancer.
|
27211795 |
2016 |
rs149006234
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the association between c.309T>G and the prognosis of lung cancer by retrospectively reviewing 453 lung cancer patients.
|
27228500 |
2016 |
rs397517108
|
|
|
0.010 |
GeneticVariation |
BEFREE |
S768I Mutation in EGFR in Patients with Lung Cancer.
|
27211795 |
2016 |
rs1389500636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Paradoxically, the tumor harbored an activating MAPK1 E322K mutation (allelic fraction 0.13), which predicts ERK activation and erlotinib resistance in EGFR-mutant lung cancer.
|
26181029 |
2015 |
rs6965469
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The EGFR rs6965469 and rs763317 polymorphisms may be risk factors for lung cancer.
|
26823874 |
2015 |
rs1051753269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that G724S mutant EGFR is oncogenic and that it differs from classic lung cancer derived EGFR mutants in that it is cetuximab responsive in vitro, yet relatively insensitive to small molecule kinase inhibitors.
|
24894453 |
2014 |
rs1171287261
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the 13 genotypes, 4 genotypes (G464E, G596R, A598T, and G606R) had not been previously reported in lung cancer.
|
24297085 |
2014 |
rs770443325
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the frequency of the HIF1A C1772T variant allele was significantly higher in lung cancer patients with TP53 LOH (P = 0.015).
|
21435097 |
2011 |
rs104886026
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, to identify genetic factors that modify lung cancer risk, CHRNA5 non-synonymous variant amino acid position 398 (D398N) was identified.
|
19577767 |
2010 |
rs1276184054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four novel mutations (E709K, V765G, Ins770G, and G1022S) and one mutation well-known in lung cancer (L858R) were identified in six HNSCC samples (7%), but we could not find any mutations in the extracellular domain of EGFR, such as EGFRvIII, in this study.
|
19726454 |
2009 |
rs727504256
|
|
|
0.010 |
GeneticVariation |
BEFREE |
E709K and Ins770G as well as L858R appear to be functional mutations based on the use of Ba/F3 cells.
|
19726454 |
2009 |
rs757699239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe how an uncharacterized lung cancer mutation in this JM activation domain (V665M) constitutively activates EGFR by augmenting its capacity to act as an acceptor in the asymmetric dimer.
|
19560417 |
2009 |
rs776375114
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four novel mutations (E709K, V765G, Ins770G, and G1022S) and one mutation well-known in lung cancer (L858R) were identified in six HNSCC samples (7%), but we could not find any mutations in the extracellular domain of EGFR, such as EGFRvIII, in this study.
|
19726454 |
2009 |
rs1408630981
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated whether the four polymorphisms (-3444C>T, -1985 G>T, I655A A>G and P1170A C>G) of the HER-2 gene are associated with the risk of lung cancer in Korean populations.
|
19055823 |
2008 |
rs1420841957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel EGFR mutation D1012H and polymorphism at exon 25 in Japanese lung cancer.
|
18478265 |
2008 |
rs377444977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most frequent point mutation (A127T) enhanced lung cancer cell growth, colony formation, focal adhesion formation, and colocalized with Bcl-2 in vitro.
|
18172305 |
2008 |
rs763317
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The EGFR rs6965469 and rs763317 polymorphisms may be risk factors for lung cancer.
|
26823874 |
2015 |