The binary logistic regression analysis showed that the AG/AA genotype of the rs2241767</span> (OR = 2.242, 95% CI: 1.037-4.878, P = 0.040) and the AG/GG genotype of the rs182052 (OR = 1.822, 95% CI: 1.111-2.987, P = 0.017) were closely related to the risk of ICAS after adjusting for conventional cardiovascular risk factors.