By and large IL-10 -592 A/C (rs1800872) polymorphism was not associated with gastrointestinal cancer risk in five genetic models (A vs. C: OR 1.00; 95% CI 0.93, 1.08; P<sub>OR</sub> = 0.960; AA vs. CC: OR 0.98; 95% CI 0.85, 1.14; P<sub>OR</sub> = 0.835; CA vs. CC: OR 1.01; 95% CI 0.94, 1.08; P<sub>OR</sub> = 0.776; AA+CA vs. CC: OR 1.03; 95% CI 0.94, 1.12; P<sub>OR</sub> = 0.592; AA vs. CA+CC: OR 0.98; 95% CI 0.87, 1.10; P<sub>OR</sub> = 0.666).