|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
No significant association between miR-146a rs2910164G/C polymorphism and gastrointestinal cancer susceptibility was found in this meta-analysis.
|
25693929 |
2014 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Case-control or cohort studies about the relationship between miR-146a rs2910164</span> G/C polymorphism and gastrointestinal cancer susceptibility were screened and included in this meta-analysis.
|
25693929 |
2014 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the miR-146a rs2910164 G > C polymorphism is a low-penetrant risk factor for digestive cancers in Chinese.
|
23534761 |
2013 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Lack of association of miR-146a rs2910164 polymorphism with gastrointestinal cancers: evidence from 10206 subjects.
|
22761848 |
2012 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Besides, the C allele of the rs2910164 might be associated with a protection from digestive cancer.
|
21637771 |
2011 |
|
rs2292832
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Mir-149 rs2292832 may modulate the risk of gastrointestinal tract cancers especially colorectal cancer.
|
30930933 |
2019 |
|
rs2292832
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The present study aimed to investigate the association between two miRNA polymorphisms (miR-499 rs3746444 and miR-149 rs2292832) and gastrointestinal (GI) cancer risk.
|
24312386 |
2013 |
|
rs2292832
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To explore the associations of SNPs within hsa-miR-605 (rs2043556) and hsa-miR-149 (rs2292832) and lifestyle-related factors with gastrointestinal cancer, a case-control study including 762 cases and 757 controls was conducted.
|
21976437 |
2012 |
|
rs4938723
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, in stratified analysis by cancer types, the rs4938723 polymorphism significantly increased the risk of gastrointestinal cancer, hepatocellular carcinoma.
|
30203457 |
2019 |
|
rs63750447
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MLH1 V384D germline variant may not only contribute to gastrointestinal cancer predisposition but may also contribute to BC in East Asians.
|
31358837 |
2019 |
|
rs11549465
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that HIF-1α rs11549465 C>T and rs11549467 G>A polymorphisms influence the pathogenesis of digestive cancers in Asians.
|
29578149 |
2018 |
|
rs11549467
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that HIF-1α rs11549465 C>T and rs11549467 G>A polymorphisms influence the pathogenesis of digestive cancers in Asians.
|
29578149 |
2018 |
|
rs920778
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SNP rs920778 is also a useful risk factor in evaluation of Asian population and digestive cancer.
|
27965458 |
2017 |
|
rs920778
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, in further stratified analyses, the variant T allele of rs920778 exhibited a significant increased risk of developing digestive cancers (dominant model: OR = 1.44; 95% CI = 1.31-1.59).
|
27010768 |
2016 |
|
rs1130409
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results of this meta-analysis collectively suggest that APE1 gene Asp148Glu variant is not a risk-conferring factor for digestive cancer.
|
26292623 |
2015 |
|
rs1130409
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the APE1 Asp148Glu polymorphism G allele is associated with an increased GI cancer risk, especially in gastric cancer.
|
25945024 |
2015 |
|
rs4938723
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The current evidence supports the conclusion that the miR-34b/c rs4938723 polymorphism decreases an individual's susceptibility to digestive cancers.
|
26320502 |
2015 |
|
rs11549465
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To understand the role of HIF-1α P582S and A588T genotypes in digestive cancer development, we conducted a comprehensive meta-analysis involving 1,517 cases and 3,740 controls.
|
24293391 |
2014 |
|
rs11549467
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To understand the role of HIF-1α P582S and A588T genotypes in digestive cancer development, we conducted a comprehensive meta-analysis involving 1,517 cases and 3,740 controls.
|
24293391 |
2014 |
|
rs2274223
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In recent years, the PLCE1 rs2274223 polymorphism has been extensively investigated as a potential risk factor for upper gastrointestinal cancers, including squamous cell carcinoma (ESCC) and gastric cancer.
|
23826241 |
2013 |
|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, the association between rs4986790 and cancer risk was statistically significant in digestive cancers (dominant model: OR = 1.76, 95% CI: 1.13-2.73) and female-specific cancers (dominant model: OR = 1.50, 95% CI: 1.16-1.94).
|
24376595 |
2013 |
|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two recent meta-analyses showed that D299G is associated with inflammatory bowel disease and gastrointestinal cancers risk, two pathological states in which the luminal microbial flora-host cells interaction may be implicated.
|
23275193 |
2013 |
|
rs2274223
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Recently, two large genome-wide association studies, conducted in Chinese populations, have reported associations between upper gastrointestinal cancer and the rs2274223, rs13042395 and rs4072037 polymorphisms in PLCE1, C20orf54 and MUC1, respectively.
|
22805490 |
2012 |
|
rs63750447
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The V384D and the Q701K variant resulted in the interaction of hMLH1 with hPMS2 at reduced efficiency and might raise the gastrointestinal cancer risk of the mutation carriers.
|
18094436 |
2007 |
|
rs11896604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs11125529 under the recessive model (OR = 2.05, 95% CI: 1.00-4.23, p = 0.038), rs843711 in recessive model (OR = 1.37, 95% CI: 1.04-1.82, p = 0.026), and rs11896604 under log-additive model (OR = 1.23, 95% CI: 1.01-1.51, p = 0.042) were associated with an increased risk of GI cancer.
|
31070019 |
2019 |