|
rs1017621656
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We now show that stable expression of oncogenic Ki-ras(G12V) c</span>onverts the HD6-4 colon cancer cell line from insensitive to TGF-beta1 to growth-promoted by TGF-beta1.
|
11029459 |
2001 |
|
rs10222633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis within linkage blocks of CASR revealed the G-G-G-G-G-A-C haplotype (rs10222633-rs10934578-rs3804592-rs17250717-A986S-R990G-rs1802757) to be associated with a decreased OS of colon cancer (HR, 3.15; 95% CI, 1.66-5.96).
|
28765616 |
2017 |
|
rs1039659576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither MTR D919G nor RFC 80G>A polymorphisms were associated with altered colon cancer risk.
|
16284371 |
2005 |
|
rs10411210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3).
|
23434150 |
2013 |
|
rs1042522
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PIA identified SNPs that may interact with the GSTT1 polymorphism, including coding polymorphisms in TP53 (Arg72Pro in p53) and CASP8 (Asp302His in caspase 8), which may modify the association between this polymorphism and colon cancer.
|
16217767 |
2006 |
|
rs1042636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis within linkage blocks of CASR revealed the G-G-G-G-G-A-C haplotype (rs10222633-rs10934578-rs3804592-rs17250717-A986S-R990G-rs1802757) to be associated with a decreased OS of colon cancer (HR, 3.15; 95% CI, 1.66-5.96).
|
28765616 |
2017 |
|
rs1042821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A study was conducted to examine whether MLH1 (-93G>A and Ile219Val) and MSH6 (Gly39Glu) polymorphisms were associated with risk of colon cancer in data from 1609 colon cancer cases and 1972 controls.
|
18523027 |
2009 |
|
rs1042821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In microsatellite stable tumors, homozygous carriers of the G39E polymorphism had an increased risk of CIMP+ colon cancer (odds ratio (OR) 2.2, 95% confidence interval (CI) 1.1, 4.2) and BRAF V600E mutation (OR 3.1, 95% CI 1.01, 9.7) in a case-control comparison.
|
19582761 |
2009 |
|
rs1044129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among seven target variants, rs1044129 at the miR-367 binding site of calcium channel ryanodine receptor gene 3 (RYR3) was associated with relapse-free survival (RFS) for colon cancer patients as a recessive model in a univariate analysis.
|
23393343 |
2013 |
|
rs10450310
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs in the 3'-untranslated region (UTR) of the gene (rs10082466, rs2120132, rs2099902, and rs10450310) were associated with an increased risk of colon cancer in African Americans.
|
22282660 |
2012 |
|
rs1045485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PIA identified SNPs that may interact with the GSTT1 polymorphism, including coding polymorphisms in TP53 (Arg72Pro in p53) and CASP8 (Asp302His in caspase 8), which may modify the association between this polymorphism and colon cancer.
|
16217767 |
2006 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
MDR1 C3435T polymorphism influences the development of colon cancer and adult acute myeloid leukemia by the association with transporting carcinogen.
|
18644389 |
2008 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Genetic testing for C3435T MDR1 gene polymorphism may be a suitable test to evaluate the risk for colon cancer in patients under 50 years of age.
|
15912392 |
2005 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The present study suggests that MDR1 2677G>T and 3435C>T polymorphism is not a risk factor for sporadic colon cancer among Bulgarians and that somatic mutation at these sites is not involved in the genesis of colon tumors.
|
17674045 |
2008 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
G2677T and C3435T polymorphisms are not associated with colon cancer risk and prognosis in a selected patient population.
|
19192650 |
2009 |
|
rs1051753269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through biochemical and cellular pharmacologic studies, we have determined that cells harboring the colon cancer-derived G719S and G724S mutants are responsive to cetuximab therapy in vitro and found that the requirement for asymmetric dimerization of these mutant EGFR to promote cellular transformation may explain their greater inhibition by cetuximab than small-molecule kinase inhibitors.
|
24894453 |
2014 |
|
rs1052133
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The association of the Ser326Cys polymorphism in the 8-oxoguanine glycosylase (OGG1) gene with a colon carcinoma and diabetes mellitus has been examined.
|
23368532 |
2013 |
|
rs1052133
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In a study of 1,604 incident colon cancer cases and 1,969 matched population-based controls genotyped for BER variants OGG1 (S326C) and XRCC1 (R194W, R280H, and R399Q), we found no associations with colon cancer overall.
|
19959686 |
2009 |
|
rs1052133
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These results suggest that the hOGG1 Ser326Cys polymorphism is probably not a major contributor to individual colon cancer susceptibility overall, but the Cys/Cys genotype may alter the impact of some environmental factors on colon cancer development.
|
12717837 |
2003 |
|
rs1052133
|
|
|
0.040 |
GeneticVariation |
BEFREE |
There was no significant association between OGG1 Ser326Cys polymorphism and CRC, but the homozygous Cys/Cys variant genotype was associated with an increased risk of colon cancer (p<0.05).
|
21899442 |
2012 |
|
rs1057519725
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, we characterized KRAS A146V biologically using colon cancer cells.
|
30448735 |
2019 |
|
rs1057519822
|
|
|
0.010 |
GeneticVariation |
BEFREE |
V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer.
|
31227518 |
2019 |
|
rs1060503118
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From the Colon Cancer Family Registry, we identified 10 carriers who had both a MUTYH mutation (6 with c.1187G>A p.(Gly396Asp), 3 with c.821G>A p.(Arg274Gln), and 1 with c.536A>G p.(Tyr179Cys)) and a MMR gene mutation (3 in MLH1, 6 in MSH2, and 1 in PMS2), 375 carriers of a single (monoallelic) MUTYH mutation alone, and 469 carriers of a MMR gene mutation alone.
|
26202870 |
2015 |
|
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we investigated the association of three functional gene variants in GC (rs2282679 T>G), DHCR7 (rs12785878 G>T) and CYP2R1 (rs10741657 A>G) with time to recurrence (TTR) in patients with stages II and III colon cancer.
|
23793229 |
2013 |
|
rs10759932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, the rs2770150 is associated with colon cancer in women aged over 50 years and is closely linked with the decreased levels of female sex hormones during the post-menopausal period (OR = 0.188, CI: 0.074-0.48, P = <0.00084). rs10759932 and rs4986790 appear to have any association with colon cancer.
|
26771524 |
2016 |