| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.100 | GeneticVariation | BEFREE | These data suggest that the BRAF V600E mutation is not the target gene for abnormal MMR in carcinogenesis in patients with sporadic endometrial cancer, unlike in colon cancer. | 19424571 | 2009 |
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0.100 | GeneticVariation | BEFREE | Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer. | 18519771 | 2008 |
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0.100 | GeneticVariation | BEFREE | We investigated the role of BRAF activating mutation (BRAF-V600E) in colorectal tumourigenesis by studying the effects of forced expression of BRAF-V600E in the 'normal' colon epithelial NCM460 cell line and by targeting endogenous BRAF-V600E in MSI-High (MSI-H) colon cancer cell lines. | 17427169 | 2007 |
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0.100 | GeneticVariation | BEFREE | The BRAF V600E mutation and 5 CpG island markers (MINT1, MINT2, MINT31, p16 and hMLH1) were assessed in 1154 cases of colon cancer. | 17096326 | 2007 |
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0.100 | GeneticVariation | BEFREE | Relationships between adenomatous polyposis coli (APC) mutations, BRAF V600E mutations, and the CpG island methylator phenotype (CIMP) in colon cancer have not been explored. | 17293392 | 2007 |
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0.100 | GeneticVariation | BEFREE | We conclude that the BRAF V600E mutation in microsatellite-stable colon cancer is associated with a significantly poorer survival in stages 2 to 4 colon cancer but has no effect on the excellent prognosis of microsatellite-unstable tumors. | 16024606 | 2005 |
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0.100 | GeneticVariation | BEFREE | Recently, an oncogenic V600E hotspot mutation within BRAF, a kinase encoding gene from the RAS/RAF/MAPK pathway, has been found to be associated with sporadic MSI-H colon cancer, but its association with HNPCC remains to be further clarified. | 15342696 | 2004 |