|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We conducted a case-control association study of <i>H. pylori</i>-infected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (<i>P =</i> 9.4 × 10<sup>-5</sup>; odds ratio = 3.88, TT + TC vs CC genotype), but not with <i>H. pylori</i> infection <i>per se</i> nor with the progression from active gastritis to gastric cancer.
|
29423095 |
2018 |
|
rs2294008
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Loss-of-function variants in ATM confer risk of gastric cancer.
|
26098866 |
2015 |
|
rs2294008
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21.
|
30281874 |
2018 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our study suggested rs2294008 in the PSCA gene to be associated with increased risk of gastric cancer and rs2070803 in MUC1 to play a protective role in a Chinese population.
|
22938426 |
2012 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
From these results we conclude that the PSCA rs2294008 polymorphism is involved in the susceptibility to GC and DU, as well as in the prognosis of the diffuse-type of GC in Caucasians.
|
25721731 |
2015 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Although modest limitations and potential bias cannot be eliminated, this meta-analysis suggests that PSCA -rs2294008C>T and -rs2976392G>A are potential factors of GC development for Eastern Asians, and future work may incorporate these findings and evaluate these variants as potential markers for screening and early diagnosis of GC.
|
22155405 |
2012 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, The T allele of PSCA rs2294008 is associated with increased risk of gastric cancer, especially intestinal type, poorly differentiated, early onset, and noncardia gastric cancer in Chinese population.
|
21268123 |
2011 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for GCa in this study population.
|
26848528 |
2016 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Two recent genome-wide association studies in Asians have reported the association between the PSCA (prostate stem cell antigen) rs2294008C>T gene polymorphism and two Helicobacter pylori infection-related diseases such as gastric cancer (GC) and duodenal ulcer (DU).
|
25721731 |
2015 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Specifically, a significant increased stomach cancer risk was associated with PSCA rs2294008 (CT vs. CC: adjusted OR = 1.37, 95% CI = 1.07-1.74, and CT/TT vs.CC: adjusted OR = 1.30, 95% CI = 1.03-1.63), PSCA rs2976392 (AG vs. GG: adjusted OR = 1.30, 95% CI = 1.02-1.65, and AG/AA vs. GG: adjusted OR = 1.26, 95% CI = 1.00-1.59), or PLCE1 rs2274223 (AG vs. AA: adjusted OR = 1.48, 95% CI = 1.15-1.90, and AG/GG vs. AA: adjusted OR = 1.45, 95% CI = 1.14-1.84), respectively.
|
25658482 |
2015 |