|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, The T allele of PSCA rs2294008 is associated with increased risk of gastric cancer, especially intestinal type, poorly differentiated, early onset, and noncardia gastric cancer in Chinese population.
|
21268123 |
2011 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
If validated in further studies, PSCA rs2294008</span> could be useful marker of sur</span>vival assessment and individualized clinical therapy for gastric cancer, particularly among the diffuse-type gastric cancer.
|
21064099 |
2011 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs2294008 polymorphism in PSCA increases the risk of noncardia gastric cancer and its precursors in white individuals but protects against proximal cancers.
|
21070776 |
2011 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recently, two genome-wide association studies identified a significant association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and risk of diffuse-type of gastric cancer in Asians and bladder cancer in Caucasians, respectively.
|
20083643 |
2010 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs2294008 C/T polymorphism of the PSCA gene was significantly associated with the susceptibility to GC.
|
20230293 |
2010 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNPs) (rs2976392 and rs2294008) in the PSCA gene were recently identified as the susceptibility loci of gastric cancer, especially in diffuse type.
|
20131315 |
2010 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We found that rs2294008 and rs2976392, which were strongly linked to each other (D' = 1.00), were significantly associated with stomach cancer risk.
|
19582881 |
2009 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, <i>P</i><0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, <i>P</i>=0.008) and rs2976392</span> (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, <i>P</i><0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20-1.92, <i>P</i><0.001) were associated with an increased gastric cancer.
|
31416884 |
2019 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
PSCA rs2294008/rs2976392 showed a significant, multiplicative interaction with H. pylori infection in risk of GC.
|
28220687 |
2017 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For SNP rs2976392, the variant A genotypes were also associated with an increased GCa risk (AG vs GG, OR=1.61, 95% CI=1.35-1.91 and AG+AA vs GG, OR=1.47, 95% CI=1.25-1.74).
|
26848528 |
2016 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Specifically, a significant increased stomach cancer risk was associated with PSCA rs2294008 (CT vs. CC: adjusted OR = 1.37, 95% CI = 1.07-1.74, and CT/TT vs.CC: adjusted OR = 1.30, 95% CI = 1.03-1.63), PSCA rs2976392 (AG vs. GG: adjusted OR = 1.30, 95% CI = 1.02-1.65, and AG/AA vs. GG: adjusted OR = 1.26, 95% CI = 1.00-1.59), or PLCE1 rs2274223 (AG vs. AA: adjusted OR = 1.48, 95% CI = 1.15-1.90, and AG/GG vs. AA: adjusted OR = 1.45, 95% CI = 1.14-1.84), respectively.
|
25658482 |
2015 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG.
|
25503145 |
2014 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that rs2294008 and rs2976392 polymorphism of PSCA is a risk-conferring factor associated with increased GC susceptibility, especially in East Asians.
|
24146278 |
2014 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although modest limitations and potential bias cannot be eliminated, this meta-analysis suggests that PSCA -rs2294008C>T and -rs2976</span>392G>A are potential factors of GC development for Eastern Asians, and future work may incorporate these findings and evaluate these variants as potential markers for screening and early diagnosis of GC.
|
22155405 |
2012 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings supported that PSCA rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer.
|
22481254 |
2012 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The two loci of PSCA (rs2294008 and rs2976392) were both significantly associated with GC susceptibility and in linkage disequilibrium.
|
22426141 |
2012 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNPs) (rs2976392 and rs2294008) in the PSCA gene were recently identified as the susceptibility loci of gastric cancer, especially in diffuse type.
|
20131315 |
2010 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that rs2294008 and rs2976392, which were strongly linked to each other (D' = 1.00), were significantly associated with stomach cancer risk.
|
19582881 |
2009 |
|
rs9297976
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We analyzed 3 SNPs in the PSCA gene (rs2294008, rs9297976 and rs12155758) which were previously found to be associated with GC risk in Europeans.
|
24023815 |
2013 |
|
rs9297976
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although rs12155758 and rs9297976 were also found associated with GC, this association appeared to be due to linkage disequilibrium with rs2294008.
|
21681742 |
2012 |
|
rs2976391
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The other three SNPs, the allele "C" of rs1800871 in IL10 (OR = 1.33, 95% CI = 1.04-1.90; P = 0.026 in the additive model; OR = 1.46, 95% CI = 1.04-2.06; P = 0.030 in the recessive model), the allele "A" of rs2976391 in PSCA (OR = 1.30, 95% CI = 1.01-1.66; P = 0.041 in the additive model and OR = 1.48, 95% CI = 1.04-2.11, P = 0.028 in the recessive model), and the allele "G" of rs17109928 in NOC3L gene (OR = 1.34, 95% CI = 1.01-1.78; P = 0.042 by additive model analysis; OR = 1.47, 95% CI = 1.04-2.07, P = 0.028 by dominant model analysis), showed an association with an increased risk of gastric cancer.
|
22796266 |
2012 |