|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU).
|
31839644 |
2019 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, <i>P</i><0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, <i>P</i>=0.008) and rs2976392 (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, <i>P</i><0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20-1.92, <i>P</i><0.001) were associated with an increased gastric cancer.
|
31416884 |
2019 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We conducted a case-control association study of <i>H. pylori</i>-infected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (<i>P =</i> 9.4 × 10<sup>-5</sup>; odds ratio = 3.88, TT + TC vs CC genotype), but not with <i>H. pylori</i> infection <i>per se</i> nor with the progression from active gastritis to gastric cancer.
|
29423095 |
2018 |
|
rs2294008
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21.
|
30281874 |
2018 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our study confirms the protective effect of MUC1 rs40</span>72037 polymorphism on the risk of GC under the dominant model.
|
28489708 |
2018 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
PSCA rs2294008/rs2976392 showed a significant, multiplicative interaction with H. pylori infection in risk of GC.
|
28220687 |
2017 |
|
rs2294008
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies.
|
26701879 |
2017 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04).
|
29028942 |
2017 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our data suggested that rs4072037 polymorphism was associated with a decreased risk of GC.
|
28561882 |
2017 |
|
rs4072037
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies.
|
26701879 |
2017 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis.
|
27001215 |
2016 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for GCa in this study population.
|
26848528 |
2016 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive.
|
26910281 |
2016 |
|
rs4072037
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
We also confirmed a previously reported association for rs4072037 in MUC1 with p=6.59×10(-8) for total gastric cancer and similar estimates for cardia and non-cardia cancers.
|
26129866 |
2016 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.
|
26910281 |
2016 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Those subjects with both the risk alleles MUC1 rs9841504 and ZBTB20 rs4072037 had a greater than 3-fold increased risk of gastric cancer.
|
27127881 |
2016 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Previous genomewide association studies identified prostate stem cell antigen (PSCA) as a gastric cancer (GC) susceptibility gene and showed an association between GC and the T allele of the single nucleotide polymorphism rs2294008 (C/T) in this gene.
|
25727947 |
2015 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The PSCA rs2294008 C>T polymorphism may be acting through induction of gastric mucosal atrophy, finally leading to development of gastric ulcer and gastric cancer in PSCA rs2294008 T allele carriers, but not duodenal ulcer.
|
25582162 |
2015 |
|
rs2294008
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Loss-of-function variants in ATM confer risk of gastric cancer.
|
26098866 |
2015 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
From these results we conclude that the PSCA rs2294008 polymorphism is involved in the susceptibility to GC and DU, as well as in the prognosis of the diffuse-type of GC in Caucasians.
|
25721731 |
2015 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Two recent genome-wide association studies in Asians have reported the association between the PSCA (prostate stem cell antigen) rs2294008C>T gene polymorphism and two Helicobacter pylori infection-related diseases such as gastric cancer (GC) and duodenal ulcer (DU).
|
25721731 |
2015 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Specifically, a significant increased stomach cancer risk was associated with PSCA rs2294008 (CT vs. CC: adjusted OR = 1.37, 95% CI = 1.07-1.74, and CT/TT vs.CC: adjusted OR = 1.30, 95% CI = 1.03-1.63), PSCA rs2976392 (AG vs. GG: adjusted OR = 1.30, 95% CI = 1.02-1.65, and AG/AA vs. GG: adjusted OR = 1.26, 95% CI = 1.00-1.59), or PLCE1 rs2274223 (AG vs. AA: adjusted OR = 1.48, 95% CI = 1.15-1.90, and AG/GG vs. AA: adjusted OR = 1.45, 95% CI = 1.14-1.84), respectively.
|
25658482 |
2015 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Loss-of-function variants in ATM confer risk of gastric cancer.
|
26098866 |
2015 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Several genetic variants including PSCA rs2294008 C>T and rs2976392 G>A, MUC1 rs4072037 T>C, and PLCE1 rs2274223 A>G have shown significant association with stomach cancer risk in the previous genome-wide association studies (GWASs).
|
25658482 |
2015 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The variant C allele of the reference SNP rs2294008 in the PSCA gene was associated with a significantly reduced risk of GC (per allele-adjusted odds ratio [aOR], 0.51; 95% confidence interval [CI], 0.33-0.77; P = .002).
|
24962126 |
2014 |