|
rs4758051
|
|
|
0.040 |
GeneticVariation |
BEFREE |
<b>Objective:</b> We conducted a three-center case-control study including 313 cases and 716 controls with the purpose to evaluate the association between five GWAS-identified <i>LMO1</i> variants (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and neuroblastoma susceptibility in eastern Chinese children.
|
30406033 |
2018 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
<b>Objective:</b> We conducted a three-center case-control study including 313 cases and 716 controls with the purpose to evaluate the association between five GWAS-identified <i>LMO1</i> variants (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and neuroblastoma susceptibility in eastern Chinese children.
|
30406033 |
2018 |
|
rs204938
|
|
|
0.040 |
GeneticVariation |
BEFREE |
<b>Objective:</b> We conducted a three-center case-control study including 313 cases and 716 controls with the purpose to evaluate the association between five GWAS-identified <i>LMO1</i> variants (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and neuroblastoma susceptibility in eastern Chinese children.
|
30406033 |
2018 |
|
rs110419
|
|
|
0.050 |
GeneticVariation |
BEFREE |
<b>Results:</b> Significant associations with neuroblastoma risk were found for four (rs110419, rs4758051, rs10840002, and rs2168101) out of the five polymorphisms.
|
30406033 |
2018 |
|
rs2168101
|
|
|
0.030 |
GeneticVariation |
BEFREE |
<b>Results:</b> Significant associations with neuroblastoma risk were found for four (rs110419, rs4758051, rs10840002, and rs2168101) out of the five polymorphisms.
|
30406033 |
2018 |
|
rs104893877
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Neuroblastoma cells were stably transfected with wild type (WT) and A53T mutant alpha-synuclein.
|
16584840 |
2006 |
|
rs1415224147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neuroblastoma cells were stably transfected with wild type (WT) and A53T mutant alpha-synuclein.
|
16584840 |
2006 |
|
rs749242026
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 3-year-old girl with relapsed high-risk NBL had a heterozygous <i>ALK</i> F1245L mutation at diagnosis, which became homozygous due to uniparental disomy (UPD) of the entire chromosome 2, confirmed by single nucleotide polymorphism array and variant allele frequency of this mutation.
|
30867766 |
2019 |
|
rs113994087
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A 77-gene ALK signature was established and successfully validated in primary neuroblastoma samples, in a neuroblastoma cell line with ALK(F1174L) and ALK(R1275Q) regulable overexpression constructs and in other ALKomas.
|
25805801 |
2015 |
|
rs281864719
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A 77-gene ALK signature was established and successfully validated in primary neuroblastoma samples, in a neuroblastoma cell line with ALK(F1174L) and ALK(R1275Q) regulable overexpression constructs and in other ALKomas.
|
25805801 |
2015 |
|
rs863225281
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A 77-gene ALK signature was established and successfully validated in primary neuroblastoma samples, in a neuroblastoma cell line with ALK(F1174L) and ALK(R1275Q) regulable overexpression constructs and in other ALKomas.
|
25805801 |
2015 |
|
rs1057520018
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A heterozygous missense mutation in STK11 (F354L) was identified in both the NB and FVPTC.
|
25751324 |
2015 |
|
rs59912467
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A heterozygous missense mutation in STK11 (F354L) was identified in both the NB and FVPTC.
|
25751324 |
2015 |
|
rs780294601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A heterozygous missense mutation in STK11 (F354L) was identified in both the NB and FVPTC.
|
25751324 |
2015 |
|
rs204926
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A major haplotype, ATC, containing rs204926, rs110420, and rs110419, conferred a significant increase in risk for NB (OR = 1.82, 95% CI: 1.41-2.36, adjusted P < 0.001).
|
26030754 |
2015 |
|
rs110420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A major haplotype, ATC, containing rs204926, rs110420, and rs110419, conferred a significant increase in risk for NB (OR = 1.82, 95% CI: 1.41-2.36, adjusted P < 0.001).
|
26030754 |
2015 |
|
rs110419
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A major haplotype, ATC, containing rs204926, rs110420, and rs110419, conferred a significant increase in risk for NB (OR = 1.82, 95% CI: 1.41-2.36, adjusted P < 0.001).
|
26030754 |
2015 |
|
rs1045485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A missense SNP in exon 10 of the CASP8 gene SNP D302H was associated with worse overall and event-free survival in patients with MYCN-amplified neuroblastoma tumors.
|
25502557 |
2014 |
|
rs1027702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A previous genome-wide association study (GWAS) identified four genetic polymorphisms (rs1027702 near <i>DUSP12</i>, rs10055201 in <i>IL31RA</i>, rs2619046 in <i>DDX4</i>, and rs11037575 in <i>HSD17B12</i> gene) that were associated with neuroblastoma susceptibility, especially for low-risk subjects.
|
28435286 |
2017 |
|
rs10055201
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A previous genome-wide association study (GWAS) identified four genetic polymorphisms (rs1027702 near <i>DUSP12</i>, rs10055201 in <i>IL31RA</i>, rs2619046 in <i>DDX4</i>, and rs11037575 in <i>HSD17B12</i> gene) that were associated with neuroblastoma susceptibility, especially for low-risk subjects.
|
28435286 |
2017 |
|
rs2619046
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A previous genome-wide association study (GWAS) identified four genetic polymorphisms (rs1027702 near <i>DUSP12</i>, rs10055201 in <i>IL31RA</i>, rs2619046 in <i>DDX4</i>, and rs11037575 in <i>HSD17B12</i> gene) that were associated with neuroblastoma susceptibility, especially for low-risk subjects.
|
28435286 |
2017 |
|
rs11994014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A previous study identified three neuroblastoma susceptibility loci (rs11994014 G>A, rs2979704 T>C, rs1059111 A>T) in <i>neurofilament light</i> (<i>NEFL</i>) gene.
|
29483959 |
2018 |
|
rs121917887
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A similar ser120-gly mutation in NME1 has been found in human neuroblastoma, suggesting that mutation in this region may be a general phenomenon related to tumor progression.
|
7794272 |
1995 |
|
rs201216664
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A similar ser120-gly mutation in NME1 has been found in human neuroblastoma, suggesting that mutation in this region may be a general phenomenon related to tumor progression.
|
7794272 |
1995 |
|
rs2271338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A three-variant ADHD risk haplotype in evolutionary conserved region 47, formed by rs17226398, rs56038622, and rs2271338, reduced enhancer activity by 40% in neuroblastoma and astrocytoma cells (p<sub>Bonferroni</sub> < .0001).
|
27692237 |
2016 |