|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
<b>Objective:</b> We conducted a three-center case-control study including 313 cases and 716 controls with the purpose to evaluate the association between five GWAS-identified <i>LMO1</i> variants (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and neuroblastoma susceptibility in eastern Chinese children.
|
30406033 |
2018 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, the rs4758051 variant appeared protective against NB in homozygous, dominant and allele genetic models, whereas the rs10840002 variant markedly decreased the risk of NB in the allele model.
|
31830377 |
2020 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In a combination analysis using Southern and Northern Chinese populations, we found that those carrying the rs110419 G, rs4758051 A or rs10840002 G allele were at decreased neuroblastoma risk, and this finding was supported by a false-positive report probability analysis.
|
29029458 |
2017 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Previous genome-wide association study (GWAS) indicated that several common genetic variations (rs110419 A > G, rs4758051 G > A, rs10840002 A > G and rs204938 A > G) in the LIM domain only 1 (LMO1) gene were associated with neuroblastoma susceptibility.
|
27009839 |
2016 |
|
rs4758051
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, the rs4758051 variant appeared protective against NB in homozygous, dominant and allele genetic models, whereas the rs10840002 variant markedly decreased the risk of NB in the allele model.
|
31830377 |
2020 |
|
rs4758051
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In a combination analysis using Southern and Northern Chinese populations, we found that those carrying the rs110419 G, rs4758051 A or rs10840002 G allele were at decreased neuroblastoma risk, and this finding was supported by a false-positive report probability analysis.
|
29029458 |
2017 |
|
rs4758051
|
|
|
0.040 |
GeneticVariation |
BEFREE |
<b>Objective:</b> We conducted a three-center case-control study including 313 cases and 716 controls with the purpose to evaluate the association between five GWAS-identified <i>LMO1</i> variants (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and neuroblastoma susceptibility in eastern Chinese children.
|
30406033 |
2018 |
|
rs4758051
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Previous genome-wide association study (GWAS) indicated that several common genetic variations (rs110419 A > G, rs4758051 G > A, rs10840002 A > G and rs204938 A > G) in the LIM domain only 1 (LMO1) gene were associated with neuroblastoma susceptibility.
|
27009839 |
2016 |
|
rs11994014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A previous study identified three neuroblastoma susceptibility loci (rs11994014 G>A, rs2979704 T>C, rs1059111 A>T) in <i>neurofilament light</i> (<i>NEFL</i>) gene.
|
29483959 |
2018 |
|
rs11994014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The neurofilament gene NEFL harbored three SNPs associated with neuroblastoma (rs11994014: Pcombined = 0.0050; OR, 0.88; rs2979704: Pcombined = 0.0072; OR, 0.87; rs1059111: Pcombined = 0.0049; OR, 0.86).
|
25312269 |
2014 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Dual-luciferase reporter assays were conducted in neuroblastoma cells to assess the promoter transcriptional activity of the rs1024611 variants (T>C) and the GRCh38.p12chr17:34252593 G>C alleles in CCL2.
|
30761072 |
2019 |
|
rs1027702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A previous genome-wide association study (GWAS) identified four genetic polymorphisms (rs1027702 near <i>DUSP12</i>, rs10055201 in <i>IL31RA</i>, rs2619046 in <i>DDX4</i>, and rs11037575 in <i>HSD17B12</i> gene) that were associated with neuroblastoma susceptibility, especially for low-risk subjects.
|
28435286 |
2017 |
|
rs11103603
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Maternal rs6776706 was associated with (RR: 0.49; 95% CI: 0.33-0.72, Q = 0.161) high-risk neuroblastoma and maternal rs11103603 (RR: 0.60; 95% CI: 0.45-0.79, Q = 0.127) was associated with neuroblastoma aged <1 year.
|
31279991 |
2019 |
|
rs12442054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One maternal SNP (rs12442054) was associated with decreased risk of neuroblastoma (RR: 0.61; 95% Confidence Interval (CI): 0.47-0.79, Q = 0.076).
|
31279991 |
2019 |
|
rs12826786
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The authors found that the rs12826786 C>T (P =.013), rs874945 C>T (P =.020), and rs1899663 C>A (P =.029) polymorphisms were significantly associated with increased neuroblastoma risk.
|
29603181 |
2018 |
|
rs7652589
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, minor alleles rs7652589 and rs1501899 are associated with reduced CaSR expression in neuroblastic tumors and neuroblastoma cell lines in which the CASR gene promoter P2 is not hypermethylated.
|
27862333 |
2017 |
|
rs874945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The authors found that the rs12826786 C>T (P =.013), rs874945 C>T (P =.020), and rs1899663 C>A (P =.029) polymorphisms were significantly associated with increased neuroblastoma risk.
|
29603181 |
2018 |
|
rs45511401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, our findings indicated a potential prognostic role of the G2012T ABCC1 polymorphism in clinically relevant subsets of patients with neuroblastoma, and provided further evidence for the ABCC1 gene being a major determinant in neuroblastoma biology.
|
21317832 |
2011 |
|
rs514049
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results from this investigation suggest that the ADAM10 rs514049-rs653765 C-A promoter haplotype is associated with: (1) higher CSF sAPPα levels in cognitively normal controls compared with Alzheimer's disease (AD) patients, (2) higher postmortem brain hippocampus, but not cerebellum, ADAM10 protein levels in subjects with low plaque scores compared with those with high plaque scores, and (3) higher promoter activity for promoter-only reporter constructs compared with promoter 3' untranslated region (3'UTR) constructs in the human neuroblastoma SHSY5Y cell line, but not in HepG2 or U118 cell lines.
|
22572541 |
2012 |
|
rs653765
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results from this investigation suggest that the ADAM10 rs514049-rs653765 C-A promoter haplotype is associated with: (1) higher CSF sAPPα levels in cognitively normal controls compared with Alzheimer's disease (AD) patients, (2) higher postmortem brain hippocampus, but not cerebellum, ADAM10 protein levels in subjects with low plaque scores compared with those with high plaque scores, and (3) higher promoter activity for promoter-only reporter constructs compared with promoter 3' untranslated region (3'UTR) constructs in the human neuroblastoma SHSY5Y cell line, but not in HepG2 or U118 cell lines.
|
22572541 |
2012 |
|
rs2271338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A three-variant ADHD risk haplotype in evolutionary conserved region 47, formed by rs17226398, rs56038622, and rs2271338, reduced enhancer activity by 40% in neuroblastoma and astrocytoma cells (p<sub>Bonferroni</sub> < .0001).
|
27692237 |
2016 |
|
rs729147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For gene-environment interaction, maternal rs729147 was associated with decreased risk of neuroblastoma among mothers with vitamin A consumption above the recommendation.
|
31279991 |
2019 |
|
rs773249771
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next, the neuroblastoma cells were transfected with the wild type GRK2 or its dominant negative mutant GRK2-K220R and the inhibition on cAMP level was determined in naïve and agonist-pretreated cells.
|
18395423 |
2008 |
|
rs1442511697
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next, the neuroblastoma cells were transfected with the wild type GRK2 or its dominant negative mutant GRK2-K220R and the inhibition on cAMP level was determined in naïve and agonist-pretreated cells.
|
18395423 |
2008 |
|
rs113994087
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The most frequent ALK mutations in neuroblastoma cause amino acid substitutions (F1174L and R1275Q) in the intracellular tyrosine kinase domain of the intact ALK receptor.
|
22072639 |
2011 |