|
rs545854
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratified analyses also showed a significant association between rs545854 and hyperuricemia among meat eaters (OR = 2.62, 95%CI = 1.09-6.26, <i>P</i> = 0.0308).
|
31031707 |
2019 |
|
rs4148500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 39 common variants were detected, with an ABCC4 variant (rs4148500) significantly associated with hyperuricemia and gout.
|
28371506 |
2017 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The strongest association was detected at SLC22A12 rs505802 for uric acid (p=2.4×10(-50)) and ABCG2 rs2231142 for hyperuricemia (p3.6×10(-10)).
|
23238572 |
2013 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs2231142 allele G was the protective factor in Uygur hyperuricemia patients.
|
30197413 |
2018 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Previous studies have suggested an association between hyperuricemia and gout susceptibility relative to dysfunctional ABCG2 variants, with rs2231142 (Q141K) being the most common.
|
30894219 |
2019 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Whereas the rs2231142 in ABCG2 gene had significant associations between gout and controls, between gout and hyperuricemia, and between hyperuricemia and controls (all p-values < 10<sup>-7</sup>), and the ORs were 4.34, 3.37 and 2.15 (all p-values < 0.001) after adjustment of potential confounders, respectively.
|
29453348 |
2018 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs2231142 SNP is associated with serum UA levels and hyperuricemia in Taiwanese patients and it occurs predominantly in male or obese patients.
|
26792383 |
2017 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Finally, we have demonstrated the utility of using small molecules to correct the Q141K defect in expression and function as a possible therapeutic approach for hyperuricemia and gout.
|
23493553 |
2013 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Three SNPs, URAT1 rs11231825, GLUT9 rs16890979 and ABCG2 rs2231142, previously associated in our population with hyperuricemia and gout, were analyzed in 27 patients with HPRT deficiency treated with allopurinol for at least 5 years.
|
29879316 |
2018 |
|
rs2231142
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Whereas the rs2231142 in ABCG2 gene had significant associations between gout and controls, between gout and hyperuricemia, and between hyperuricemia and controls (all p-values < 10<sup>-7</sup>), and the ORs were 4.34, 3.37 and 2.15 (all p-values < 0.001) after adjustment of potential confounders, respectively.
|
29453348 |
2018 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Adenosine 5'-triphosphate-binding cassette subfamily G member 2 (ABCG2) is a urate transporter, and common dysfunctional variants of ABCG2, non-functional Q126X (rs72552713) and semi-functional Q141K (rs2231142), are risk factors for hyperuricemia and gout.
|
29342419 |
2018 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The contributions of age, sex, ancestry, Q141K genotype for ABCG2, FCU, sugar-sweetened beverage and alcohol consumption, metabolic syndrome disorders and measures of renal function to the risk of hyperuricaemia were evaluated by comparing hyperuricaemic (serum urate≥0.42 mmol/L, n=448) with normouricaemic (serum urate<0.42 mmol/L, n=344) participants using stepwise logistic regression.
|
26835700 |
2016 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Associations of the rs2231142 variant with serum uric acid levels and prevalence of gout and hyperuricaemia were examined.
|
20421215 |
2010 |
|
rs199897813
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
rs2054576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a hyperuricemia susceptible loci (rs2054576 in ABCG2, OR, 1.883; P = 4.7 × 10⁻⁸) that passed a genome-wide significance threshold, adjusted by clinical variables (male, age, BMI, current alcohol, and creatinine).
|
28776340 |
2017 |
|
rs72552713
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Adenosine 5'-triphosphate-binding cassette subfamily G member 2 (ABCG2) is a urate transporter, and common dysfunctional variants of ABCG2, non-functional Q126X (rs72552713) and semi-functional Q141K (rs2231142), are risk factors for hyperuricemia and gout.
|
29342419 |
2018 |
|
rs4994
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The common polymorphism rs4994 [c. T387C, p. Trp64Arg (W64R)] of the lipolysis regulator beta-3-adrenergic receptor (ADRB3) was identified as a marker in the pathogenesis of hyperuricemia.
|
21285172 |
2011 |
|
rs4994
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Trp64Arg polymorphism was associated with hyperuricemia in a Chinese male population and should be an independent risk factor for hyperuricemia.
|
23729572 |
2013 |
|
rs4994
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Trp64Arg polymorphism of the ADRB3 gene predicted the risk of developing hyperuricemia in this adult population.
|
20008926 |
2010 |
|
rs4994
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Trp64Arg polymorphism of the beta-3 adrenergic receptor may be independently associated with hyperuricemia in males.
|
17225053 |
2007 |
|
rs6903956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings are the first to establish a genetic link of a CAD-associated rs6903956 with aHU in a Han Chinese population, providing the genetic evidence to support the close relationship between hyperuricemia and CAD.
|
25928384 |
2015 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs671 major G allele and wGRS were not associated with hyperuricemia.
|
31338989 |
2019 |
|
rs200548390
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
rs141158222
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
rs61754122
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |