Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.020 GeneticVariation BEFREE The MTHFR C677T genotype was determined in 74 patients with histologically-verified primary brain tumors and 98 cancer-free control subjects. 16821630

2006

dbSNP: rs1045485
rs1045485
0.020 GeneticVariation BEFREE The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor. 18398042

2008

dbSNP: rs1801516
rs1801516
ATM
0.010 GeneticVariation BEFREE Three-hit hypothesis in astrocytoma: tracing the polymorphism D1853N in ATM gene through a pedigree of the proband affected with primary brain tumor. 18465141

2008

dbSNP: rs121913500
rs121913500
0.010 GeneticVariation BEFREE High-throughput immunohistochemical profiling of primary brain tumors and non-neoplastic systemic organs with a specific antibody against the mutant isocitrate dehydrogenase 1 R132H protein. 21213123

2011

dbSNP: rs1217691063
rs1217691063
0.020 GeneticVariation BEFREE Association of the MTHFR C677T polymorphism with primary brain tumor risk. 23846816

2013

dbSNP: rs1799969
rs1799969
0.010 GeneticVariation BEFREE This study provides the first evidence that ICAM-1 R241G SNP significantly contributes to the risk of primary brain tumors in a Turkish population. 24289603

2013

dbSNP: rs1045485
rs1045485
0.020 GeneticVariation BEFREE D302H polymorphism of CASP8 gene may be associated with increased risk of glioma but larger study groups in different ethnic populations are needed to better elucidate the role of CASP8 gene polymorphism in the pathogenesis of primary brain tumors. 26359420

2016

dbSNP: rs1052576
rs1052576
0.010 GeneticVariation BEFREE Role of Caspase-9 Gene Ex5+32 G>A (rs1052576) Variant in Susceptibility to Primary Brain Tumors. 28870924

2017

dbSNP: rs113488022
rs113488022
0.020 GeneticVariation BEFREE Numerous case reports in adult primary brain tumors with BRAF-V600E mutations demonstrate signals of BRAFi activity in the brain. 30265855

2018

dbSNP: rs121913377
rs121913377
0.020 GeneticVariation BEFREE Numerous case reports in adult primary brain tumors with BRAF-V600E mutations demonstrate signals of BRAFi activity in the brain. 30265855

2018

dbSNP: rs113488022
rs113488022
0.020 GeneticVariation BEFREE Dual BRAF/MEK inhibitor therapy represents an exciting treatment option for patients with BRAF V600E primary brain tumors. 31675726

2019

dbSNP: rs121913377
rs121913377
0.020 GeneticVariation BEFREE Dual BRAF/MEK inhibitor therapy represents an exciting treatment option for patients with BRAF V600E primary brain tumors. 31675726

2019