|
rs2235371
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Association between the IRF6 rs2235371 polymorphism and the risk of nonsyndromic cleft lip with or without cleft palate in Chinese Han populations: A meta-analysis.
|
29017114 |
2017 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
MTHFR c.677C>T is a risk factor for non-syndromic cleft lip with or without cleft palate in Chile.
|
27387868 |
2016 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Maternal C677T MTHFR genotype has been identified as important factor in cleft lip with or without cleft palate (CL/P) etiology.
|
21781437 |
2013 |
|
rs2235371
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Conclusion : Our results confirmed the involvement of the IRF6 variants rs642961 and rs2235371 in the etiology of nonsyndromic cleft lip with or without cleft palate</span> in a Chinese population.
|
23509905 |
2013 |
|
rs2235371
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In the single locus analyses, we found rs642961 AG and AG/AA genotypes were associated with increased risk of NSOC, especially cleft lip with or without cleft palate (CL/P) and cleft lip with cleft palate (CLP), while significantly decreased risks were associated with rs2235371 CT and CT/TT genotypes.
|
20799332 |
2010 |
|
rs2235371
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To investigate whether an association occurred between the IRF6 G820A polymorphism and nonsyndromic cleft lip with or without cleft palate (CL+/-P) or cleft palate only (CPO) in Chinese patients.
|
19115793 |
2009 |
|
rs2235371
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Significant association between IRF6 820G->A and non-syndromic cleft lip with or without cleft palate in the Thai population.
|
15994871 |
2005 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The 677 C --> T polymorphism in the 5-10 methylenetetrahydrofolate reductase (MTHFR) gene has been associated with nonsyndromic cleft lip with or without cleft palate (CL/P) in some populations, but not others.
|
15054400 |
2004 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Infant and parental MTHFR C677T and MTHFR A1298C genotypes and haplotypes were not associated with CL(P) risk in the case-control and transmission disequilibrium test analyses.
|
12672677 |
2003 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our results did not indicate increased risks for CLP among infants homozygous for the C677T genotype, nor do they indicate an interaction between infant C677T genotype and maternal multivitamin use on the occurrence of CLP.
|
9843036 |
1998 |
|
rs642961
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Conclusion : Our results confirmed the involvement of the IRF6 variants rs642961 and rs2235371 in the etiology of nonsyndromic cleft lip with or without cleft palate in a Chinese population.
|
23509905 |
2013 |
|
rs1546124
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also found association of SNP rs1546124 with cleft palate alone (CP) in South Americans (Guatemala and ECLAMC) and combined Hispanics (Guatemala, ECLAMC, and Texas Hispanics; p = .03 for both comparisons) and with both cleft lip with cleft palate (CLP; p = .04) and CL(P) (p = .02) in North Americans.
|
20815724 |
2011 |
|
rs1546124
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, the CC genotype at rs1546124 was associated with increased risk for cleft lip with or without cleft palate (CL/P; OR, 2.11; 95% CI, 1.41-3.15; p(correct) = 1.5 × 10(-4) ) and for cleft palate only (CPO; OR, 2.93; 95% CI, 1.69-5.07; p(correct) = 5.4 × 10(-4) ), whereas the T allele of rs4783099 was associated with decreased risk for CPO.
|
21800413 |
2011 |
|
rs642961
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the single locus analyses, we found rs642961 AG and AG/AA genotypes were associated with increased risk of NSOC, especially cleft lip with or without cleft palate (CL/P) and cleft lip with cleft palate (CLP), while significantly decreased risks were associated with rs2235371 CT and CT/TT genotypes.
|
20799332 |
2010 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population.
|
19419265 |
2009 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Infant and parental MTHFR C677T and MTHFR A1298C genotypes and haplotypes were not associated with CL(P) risk in the case-control and transmission disequilibrium test analyses.
|
12672677 |
2003 |
|
rs1972041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of single nucleotide polymorphisms in TPM1 rs11071720, rs3803499, rs12148828, and rs1972041 with the risk of nonsyndromic cleft lip with or without cleft palate in a sample of the Iranian population, a preliminary report.
|
30888054 |
2019 |
|
rs12532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In an analysis stratified according to disease type, rs12532 was associated with the risk of cleft palate only (CPO) but not with the risk of cleft lip with or without cleft palate (CL/P).
|
29664137 |
2018 |
|
rs1258763
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the cleft subgroup, we found that the GREM1 rs1258763 GA genotype might contribute to the elevated risk of the cleft lip with or without cleft palate (CL/P) (P = .029).
|
29149498 |
2018 |
|
rs201002930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we aimed to inspect the relationship between WNT3 (rs3809857 and rs9890413), WNT3A (rs752107 and rs3121310), and WNT10a rs201002930 (c.392 C>T) polymorphisms and nonsyndromic cleft lip with or without cleft palate in an Iranian population.
|
29356097 |
2018 |
|
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that compared with the C allele, the rs2910164 G allele of pre-miR-146a was associated with an increased risk of NSOC (additive model: odds ratio [OR] = 1.17, 95% confidence interval [CI]: 1.06-1.30, P = 0.002), including both cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO).
|
29484780 |
2018 |
|
rs3121310
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant association was observed between the rs752107 and rs3121310 variants and risk/protection of nonsyndromic cleft lip with or without cleft palate.
|
29356097 |
2018 |
|
rs3809857
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings suggest that the rs3809857 polymorphism significantly decreased the risk of nonsyndromic cleft lip with or without cleft palate in codominant (odds ratio = 0.16, 95% confidence interval = 0.03-0.75, P = 0.020, TT vs GG), recessive (odds ratio = 0.16, 95% confidence interval = 0.03-0.72, P = 0.009, TT vs GG + GT) inheritance models.
|
29356097 |
2018 |
|
rs7552
|
|
|
0.010 |
GeneticVariation |
BEFREE |
2p24.2 (rs7552) is a susceptibility locus for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.
|
29488623 |
2018 |
|
rs9890413
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs9890413 variant marginally decreased the risk of nonsyndromic cleft lip with or without cleft palate in codominant (odds ratio = 0.41, 95% confidence interval = 0.17-0.99, P = 0.047, AG vs AA) model.
|
29356097 |
2018 |