Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1934179
rs1934179
DGKK
0.720 GeneticVariation BEFREE Six SNPs (rs1934179, rs4143304, rs9969978, rs1934188, rs7063116 and rs1934190) were significantly associated with mild/moderate hypospadias (ORs >1, P < 0.05), and rs1934179 was significantly associated with severe hypospadias (OR > 1, P < 0.05). 25327554

2015
dbSNP: rs1934179
rs1934179
DGKK
A 0.720 GeneticVariation GWASDB Common variants in DGKK are strongly associated with risk of hypospadias. 21113153

2011
dbSNP: rs1934179
rs1934179
DGKK
0.720 GeneticVariation BEFREE Individual genotyping of two SNPs (rs1934179 and rs7063116) in DGKK, encoding diacylglycerol kinase κ, produced compelling evidence for association with hypospadias in the discovery sample (allele-specific odds ratio (OR) = 2.5, P = 2.5 × 10⁻¹¹ and OR = 2.3, P = 2.9 × 10⁻⁹, respectively) and in the Dutch (OR = 3.9, P = 2.4 × 10⁻⁵ and OR = 3.8, P = 3.4 × 10⁻⁵) and Swedish (OR = 2.5, P = 2.6 × 10⁻⁸ and OR = 2.2, P = 2.7 × 10⁻⁶) replication samples. 21113153

2011
dbSNP: rs3816183
rs3816183
HAAO ; MTA3
0.710 GeneticVariation BEFREE Single nucleotide polymorphism rs3816183 of HAAO was significantly associated with susceptibility to hypospadias in general (p = 0.0019) and to anterior/middle hypospadias (p = 0.0283) and posterior hypospadias (p = 0.0226), while single nucleotide polymorphism rs6499755 of IRX6 showed an association with susceptibility to anterior/middle hypospadias (p = 0.0472). 30063927

2019
dbSNP: rs4554617
rs4554617
DGKK
0.710 GeneticVariation BEFREE Five SNPs (rs2211122, rs4554617, rs7058226, rs7063116, and rs5915254) in DGKK were significantly associated with hypospadias (P < 0.05), with odds ratios (ORs) of 1.64-1.76. 28597849

2019
dbSNP: rs6499755
rs6499755 		0.710 GeneticVariation BEFREE Single nucleotide polymorphism rs3816183 of HAAO was significantly associated with susceptibility to hypospadias in general (p = 0.0019) and to anterior/middle hypospadias (p = 0.0283) and posterior hypospadias (p = 0.0226), while single nucleotide polymorphism rs6499755 of IRX6 showed an association with susceptibility to anterior/middle hypospadias (p = 0.0472). 30063927

2019
dbSNP: rs3816183
rs3816183
HAAO ; MTA3
T 0.710 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs4554617
rs4554617
DGKK
C 0.710 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs6499755
rs6499755 		C 0.710 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs10214930
rs10214930
TAX1BP1
G 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs10762738
rs10762738
KCNMA1 ; KCNMA1-AS1
G 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs10979
rs10979
PHACTR2 ; PHACTR2-AS1
A 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs11749327
rs11749327
EXOC3
C 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs13124827
rs13124827 		C 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs143136847
rs143136847
CCDC59
G 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs16937456
rs16937456
LOC105375894
G 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs17208368
rs17208368 		A 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs17262815
rs17262815
CCDC26
C 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs17747401
rs17747401
ADK
T 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs1801085
rs1801085
HOXA3 ; HOXA4 ; HOXA-AS2
G 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs1858800
rs1858800
ZFHX3
T 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs1918690
rs1918690
DNAH6
T 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs2999052
rs2999052
EEFSEC
T 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs3743104
rs3743104
GREM1
G 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014
dbSNP: rs3812762
rs3812762
DENND2B
G 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify variants in developmental genes associated with hypospadias. 25108383

2014