|
rs2910164
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We aim to analyze the association between NF-κB1 encoding p50 (rs28362491, -94 in.ertion/deletion ATTG) and miR-146a (rs2910164, G > C) polymorphisms and risk of aGVHD.
|
31813598 |
2019 |
|
rs1800795
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, the IL-6R rs4845618 donor genotype showed an association with severe acute graft-versus-host disease (GVHD), whereas the donor genotype of the IL-6 SNP rs1800795 was associated with decreased survival 100 days post-transplant.
|
29513361 |
2018 |
|
rs2910164
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In humans, the minor genotype of the single nucleotide polymorphism rs2910164 in HCT donors, which reduces expression of miR-146a, was associated with severe acute GVHD (grade III/IV).
|
25205119 |
2014 |
|
rs4693608
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Similarly, the discrepancy in rs4693608 HPSE SNP between recipients and donors was found to be a more significant factor for the risk of aGVHD than patient genotype.
|
24319286 |
2014 |
|
rs1800795
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Similar to previous publications, the IL6 donor genotype for rs1800795 was associated with a 20%-50% increased risk for grade IIb-IV aGVHD after unrelated HCT in the allelic (adjusted P = .011) and recessive (adjusted P = .0013) models.
|
22282500 |
2012 |
|
rs4693608
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The present study indicates a highly significant correlation of HPSE gene SNPs rs4693608 and rs4364254 and their combination with the risk of developing acute GVHD.
|
20075159 |
2010 |
|
rs2310241
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Donor risk alleles in rs22441131 (<i>P</i><sub>meta</sub> = .00026) and rs2310241 (<i>P</i><sub>meta</sub> = .00033) increased the cumulative incidence of aGVHD death up to fourfold and were associated with high sST2 levels.
|
31455667 |
2019 |
|
rs28362491
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We aim to analyze the association between NF-κB1 encoding p50 (rs28362491, -94 in.ertion/deletion ATTG) and miR-146a (rs2910164, G > C) polymorphisms and risk of aGVHD.
|
31813598 |
2019 |
|
rs1129055
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, analysis of gene-gene interaction between <i>CD86</i> and <i>CTLA-4</i> showed that having both the A allele for <i>CD86</i> rs1129055 and the <i>CTLA-4</i> CT60GG genotype in recipients increased the risk of aGvHD about 3.5 times.
|
29577049 |
2018 |
|
rs2232365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs3761549, rs5902434, and rs2232365 are associated with an increased risk of acute GVHD and decreased risk of post-HSCT infection.
|
30027704 |
2018 |
|
rs2278293
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recipient and donor IMPDH genotypes (rs11706052, rs2278294, rs2278293) were not associated with day 28 T cell chimerism, acute graft-versus-host disease (GVHD), disease relapse, cytomegalovirus reactivation, nonrelapse mortality, or overall survival.
|
29656138 |
2018 |
|
rs2278294
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recipient and donor IMPDH genotypes (rs11706052, rs2278294, rs2278293) were not associated with day 28 T cell chimerism, acute graft-versus-host disease (GVHD), disease relapse, cytomegalovirus reactivation, nonrelapse mortality, or overall survival.
|
29656138 |
2018 |
|
rs3092920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients and Methods Three CD40L SNPs (rs3092920, rs3092952, rs3092936) were analyzed for association with transplant-associated thrombotic microangiopathy, overall nonrelapse mortality (NRM), and NRM after acute graft-versus-host disease in 294 recipients of alloSCT without statin-based endothelial prophylaxis (SEP).
|
29369699 |
2018 |
|
rs3092936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results The rs3092936 CC/CT genotype was associated with an increased risk of transplant-associated thrombotic microangiopathy ( P = .001), overall NRM ( P = .03), and NRM after acute graft-versus-host disease ( P = .01).
|
29369699 |
2018 |
|
rs3092952
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients and Methods Three CD40L SNPs (rs3092920, rs3092952, rs3092936) were analyzed for association with transplant-associated thrombotic microangiopathy, overall nonrelapse mortality (NRM), and NRM after acute graft-versus-host disease in 294 recipients of alloSCT without statin-based endothelial prophylaxis (SEP).
|
29369699 |
2018 |
|
rs3761549
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate analysis showed that the TT genotype of rs3761549 was an independent risk factor for occurrence of acute GVHD (P=0.032, hazard ratio=5.6).
|
30027704 |
2018 |
|
rs4415345
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In multivariable analysis (with a SNP × graft source interaction term in CTN-0201 and a SNP × conditioning intensity term in CTN-0901), DEFA5 rs4415345 and rs4610776 were associated with altered incidence of aGVHD grade II-IV [rs4415345 G vs. C: hazard ratio (HR) 0·58, 95% confidence interval (95% CI) 0·37-0·92, P = 0·02; rs4610776 T vs. A: HR 1·53, 95% CI 1·01-2·32, P = 0·05] in CTN-0201, but not CTN-0901, suggesting a stronger effect in bone marrow allografts.
|
30004111 |
2018 |
|
rs4610776
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In multivariable analysis (with a SNP × graft source interaction term in CTN-0201 and a SNP × conditioning intensity term in CTN-0901), DEFA5 rs4415345 and rs4610776 were associated with altered incidence of aGVHD grade II-IV [rs4415345 G vs. C: hazard ratio (HR) 0·58, 95% confidence interval (95% CI) 0·37-0·92, P = 0·02; rs4610776 T vs. A: HR 1·53, 95% CI 1·01-2·32, P = 0·05] in CTN-0201, but not CTN-0901, suggesting a stronger effect in bone marrow allografts.
|
30004111 |
2018 |
|
rs4845618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the IL-6R rs4845618 donor genotype showed an association with severe acute graft-versus-host disease (GVHD), whereas the donor genotype of the IL-6 SNP rs1800795 was associated with decreased survival 100 days post-transplant.
|
29513361 |
2018 |
|
rs6897932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, donor carriage of the rs6897932 T allele was associated with reduced sIL-7Rα levels, increased risk of grades II-IV aGVHD (OR=2.4, P=0.055) and increased transplant-related mortality (CC=4.5%, CT=21.4% and TT=27.3%, P=0.0037).
|
28863969 |
2018 |
|
rs9277534
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evolutionary analysis revealed that rs9277534 represented a highly conserved HLA-DPB1 Ex3-3'UTR region and may provoke aGVHD differently to TCE mismatching algorithm, reflecting exon 2 polymorphisms.
|
29246901 |
2018 |
|
rs361525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One of the two most widely investigated SNPs (rs361525G>A) was marginally associated with increased risk of grade II-IV aGvHD in random-effects meta-analysis of six studies (627 patients in total, risk ratio=1.29, 95% confidence interval=0.99-1.69, P=0.06).
|
28692026 |
2017 |
|
rs7588571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no association between rs7588571 polymorphism and the incidence of acute GVHD.
|
28945764 |
2017 |
|
rs9277378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three novel susceptibility loci in the HLA-DP region of recipient genomes that were associated with III-IV acute GvHD (rs9277378, P=1.58E-09; rs9277542, P=1.548E-06 and rs9277341, P=7.718E-05).
|
27595289 |
2017 |
|
rs17114808
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The incidence of acute GVHD among patients homozygous for CC at SUFU rs17114808 was 69%, which was significantly higher than the 8% rate observed in CT heterozygous patients (p = 0.0002).
|
26067905 |
2015 |