Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs17036170
rs17036170
0.700 GeneticVariation GWASDB Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs. 22968431

2012

dbSNP: rs1495741
rs1495741
0.030 GeneticVariation BEFREE Two SNPs in NAT2 (rs1041983 and rs1495741) and NAT2 slow acetylators (SA) were significantly associated with INH-DILI (OR (95% CI) = 13.86 (4.30-44.70), 0.10 (0.03-0.33) and 9.98 (3.32-33.80), respectively). 29036176

2017

dbSNP: rs1495741
rs1495741
0.030 GeneticVariation BEFREE tagSNP rs1495741 as a useful molecular marker to predict antituberculosis drug-induced hepatotoxicity. 27104815

2016

dbSNP: rs1495741
rs1495741
0.030 GeneticVariation BEFREE The NAT2 tag SNP rs1495741 correlates with the susceptibility of antituberculosis drug-induced hepatotoxicity. 23407048

2013

dbSNP: rs2287622
rs2287622
0.020 GeneticVariation BEFREE A common variant (rs2287622; p.V444A) in the gene encoding BSEP has been associated with an increased risk of cholestatic DILI. 30608704

2019

dbSNP: rs2287622
rs2287622
0.020 GeneticVariation BEFREE Patients carrying the C allele in the ABCB11 1331T>C polymorphism are at increased risk of developing hepatocellular type of DILI, when taking drugs containing a carbocyclic system with aromatic rings. 23701583

2013

dbSNP: rs10946737
rs10946737
0.010 GeneticVariation BEFREE On the basis of this case-control study, SNP rs10946737 in FAM65B may be associated with susceptibility to ATDH in Chinese Han anti-TB treatment patients. 30720667

2019

dbSNP: rs117806152
rs117806152
0.010 GeneticVariation BEFREE Rs79280755 increased the risk of ATDILI significantly whether in additive (OR = 3.218, 95% CI: 1.686-6.139, PBonferroni correction = .003) or dominant model (PBonferroni correction = .003), as well as rs117806152 (Additive model: PBonferroni correction = .05; dominant model: PBonferroni correction = .03). 31689868

2019

dbSNP: rs2306283
rs2306283
0.010 GeneticVariation BEFREE We found that rs12422149 of SLCO2B1, rs2032582_AT of ABCB1, rs2306283 of SLCO1B1 and rs4148323 of UGT1A1 exhibited a significant association with MMI-DILI; however, no significant difference existed after Bonferroni correction. 31240859

2019

dbSNP: rs2476601
rs2476601
0.010 GeneticVariation BEFREE We associated idiosyncratic DILI with rs2476601, a nonsynonymous polymorphism that encodes a substitution of tryptophan with arginine in the protein tyrosine phosphatase, nonreceptor type 22 gene (PTPN22) (odds ratio [OR] 1.44; 95% confidence interval [CI] 1.28-1.62; P = 1.2 × 10<sup>-9</sup> and replicated the finding in the validation set (OR 1.48; 95% CI 1.09-1.99; P = .01). 30664875

2019

dbSNP: rs4148323
rs4148323
0.010 GeneticVariation BEFREE We found that rs12422149 of SLCO2B1, rs2032582_AT of ABCB1, rs2306283 of SLCO1B1 and rs4148323 of UGT1A1 exhibited a significant association with MMI-DILI; however, no significant difference existed after Bonferroni correction. 31240859

2019

dbSNP: rs4430924
rs4430924
0.010 GeneticVariation BEFREE After correcting for weight and hepatoprotectant use, conditional logistic regression analysis showed that patients carrying the AA genotype of rs4430924 in</span> XPO1 were at higher risk of anti-TB drug-induced hepatotoxicity than those carrying the GG genotype based on the subgroup of probable cases (adjusted OR, 1.938; 95%CI, 1.035-3.628; P = .039), and marginally significant differences were also found under the recessive model (P = .048) and the additive model (P = .047). 30817003

2019

dbSNP: rs1800796
rs1800796
0.010 GeneticVariation BEFREE rs1800796 of the IL6 gene is associated with increased risk for anti-tuberculosis drug-induced hepatotoxicity in Chinese Han children. 30029918

2018

dbSNP: rs1041983
rs1041983
0.010 GeneticVariation BEFREE Two SNPs in NAT2 (rs1041983 and rs1495741) and NAT2 slow acetylators (SA) were significantly associated with INH-DILI (OR (95% CI) = 13.86 (4.30-44.70), 0.10 (0.03-0.33) and 9.98 (3.32-33.80), respectively). 29036176

2017

dbSNP: rs114577328
rs114577328
0.010 GeneticVariation BEFREE We associated DILI with rs114577328 (a proxy for A*33:01 a HLA class I allele; odds ratio [OR], 2.7; 95% confidence interval [CI], 1.9-3.8; P = 2.4 × 10<sup>-8</sup>) and with rs72631567 on chromosome 2 (OR, 2.0; 95% CI, 1.6-2.5; P = 9.7 × 10<sup>-9</sup>). 28043905

2017

dbSNP: rs116561224
rs116561224
0.010 GeneticVariation BEFREE We did not associate any specific drug classes with genetic polymorphisms, except for statin-associated DILI, which was associated with rs116561224 on chromosome 18 (OR, 5.4; 95% CI, 3.0-9.5; P = 7.1 × 10<sup>-9</sup>). 28043905

2017

dbSNP: rs72631567
rs72631567
0.010 GeneticVariation BEFREE We associated DILI with rs114577328 (a proxy for A*33:01 a HLA class I allele; odds ratio [OR], 2.7; 95% confidence interval [CI], 1.9-3.8; P = 2.4 × 10<sup>-8</sup>) and with rs72631567 on chromosome 2 (OR, 2.0; 95% CI, 1.6-2.5; P = 9.7 × 10<sup>-9</sup>). 28043905

2017

dbSNP: rs80292941
rs80292941
0.010 GeneticVariation BEFREE Our findings strongly suggest that <i>LINC00152</i> may promote TB progression and highlight rs80292941 single nucleotide polymorphism as a novel predisposition marker for antituberculosis drug-induced hepatotoxicity. 29383173

2017

dbSNP: rs2741045
rs2741045
0.010 GeneticVariation BEFREE We observed statistically significant associations between SNP rs2741045 and DILI at</span> both allele and genotype levels (allele: P=0.032; genotype: P=0.029; after Bonferroni correction). 25446781

2015

dbSNP: rs138642043
rs138642043
0.010 GeneticVariation BEFREE On sequencing, ATP8B1 was normal in both patients although the younger was heterozygous for the c.2093G>A mutation in ABCB11, a polymorphism previously encountered in drug-induced liver injury. 23750872

2013

dbSNP: rs231775
rs231775
0.010 GeneticVariation BEFREE A significant association was found between the rs231775 genotype and an early onset of DILI in the recipients. 23300559

2012

dbSNP: rs3087243
rs3087243
0.010 GeneticVariation BEFREE We investigated the association of 5 CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) recipients. 23300559

2012

dbSNP: rs4553808
rs4553808
0.010 GeneticVariation BEFREE We investigated the association of 5 CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) recipients. 23300559

2012

dbSNP: rs5742909
rs5742909
0.010 GeneticVariation BEFREE We investigated the association of 5 CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) recipients. 23300559

2012

dbSNP: rs733618
rs733618
0.010 GeneticVariation BEFREE Five haplotypes were estimated for 4 SNPs (excluding rs733618); the frequency of haplotype ACGG was significantly higher in the DILI group (68.9%) than in the non-DILI group (61.1%) (p = 0.041). 23300559

2012