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rs567534295
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analyses performed under logistic model, linear mixed model, and model incorporating correlations identified nine significant associations with three gynecologic diseases including four novel findings (rs79219469:C > T, LINC02183, P = 3.3 × 10<sup>-8</sup> and rs567534295:C > T, BRCA1, P = 3.1 × 10<sup>-8</sup> with OC, rs150806792:C > T, INS-IGF2, P = 4.9 × 10<sup>-8</sup> and rs140991990:A > G, SOX9, P = 3.3 × 10<sup>-8</sup> with UCC).
|
31488892 |
2020 |
|
rs12373237
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CC homozygous mutation of rs12373237 was highly correlated with the onset of ovarian cancer (OR=4.333, P=0.028).
|
31402958 |
2019 |
|
rs137853011
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This karyotype phenotype was not observed in other tested tissues or in an ovarian cancer patient with a different homozygous missense mutation in <i>CHEK2</i> (c.1283C>T; p.Ser428Phe).
|
30858171 |
2019 |
|
rs200640585
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PMS2 germline mutation c.943C>T (p.Arg315*)-induced Lynch syndrome-associated ovarian cancer.
|
31056861 |
2019 |
|
rs2516839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, our results suggest that the rs2516839 polymorphism in USF1 gene may associate with the efficacy and safety of paclitaxel-based chemotherapy and prognosis in the treatment of OC.
|
29322800 |
2019 |
|
rs2699887
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interaction between PIK3CA rs2699887 SNP and age, number of liveborn, tobacco, alcohol, a family history of ovarian cancer and other factors are associated with ovarian cancer risk.
|
31288947 |
2019 |
|
rs3212986
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ERCC1 rs3212986 (C/A) polymorphisms posed an increased risk for breast and ovarian cancer as whole (A vs C: OR = 1.12, 95% CI = 1.01-1.25; AA + CA vs CC: OR = 1.11, 95% CI = 1.02-1.22), and presented especially higher risk for ovarian cancer (A vs C: OR = 1.31, 95% CI = 1.05-1.63; AA vs CA + CC: OR = 1.66, 95% CI = 1.12-2.47; AA vs CC: OR = 1.72, 95% CI = 1.12-2.64).
|
31081240 |
2019 |
|
rs3737787
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study was supposed to investigate the correlation between the functional single nucleotide polymorphisms (SNPs) (rs2516839 and rs3737787) in USF1 gene and the efficacy and safety of paclitaxel-based chemotherapy and prognosis in the treatment of ovarian cancer (OC).
|
29322800 |
2019 |
|
rs3976507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interaction between PIK3CA rs3976507 and rs6443626 loci, and factors such as BMI, number of liveborn, tobacco, alcohol, and family history of ovarian cancer are associated with ovarian cancer risk.
|
31288947 |
2019 |
|
rs587778617
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PMS2 germline mutation c.943C>T (p.Arg315*)-induced Lynch syndrome-associated ovarian cancer.
|
31056861 |
2019 |
|
rs6443626
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interaction between PIK3CA rs3976507 and rs6443626 loci, and factors such as BMI, number of liveborn, tobacco, alcohol, and family history of ovarian cancer are associated with ovarian cancer risk.
|
31288947 |
2019 |
|
rs79722116
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, two non-synonymous SNPs rs201407189 (c.973G>A, p.A325T) and rs1800367 (c.1345G>A, p.V449M), and two synonymous SNPs rs55719336 (c.816C>T, p.I272I) and rs79722116 (c.1407G>A, p.T469T) were identified in FBOC patients.
|
30967997 |
2019 |
|
rs80356897
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, two non-synonymous SNPs rs201407189 (c.973G>A, p.A325T) and rs1800367 (c.1345G>A, p.V449M), and two synonymous SNPs rs55719336 (c.816C>T, p.I272I) and rs79722116 (c.1407G>A, p.T469T) were identified in FBOC patients.
|
30967997 |
2019 |
|
rs80357268
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRCA1, p.(Val1833Met) is possibly a disease-associated variant, supported by a likelihood ratio of 1.88, while a correlation to ovarian cancer is suspected.
|
31447071 |
2019 |
|
rs1136905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We established that <i>TP53</i> "hotspot" mutations (c.659A>G; p.Y220C and c.733G>A; p.G245S) expressed by two different patients' tumors were both immunogenic in the context of HLA-DRB3*02:02.<b>Conclusions:</b> Mutation-reactive T cells infiltrated ovarian cancer metastases at sufficient frequencies to warrant their investigation as adoptive cell therapy.
|
29853601 |
2018 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, for detecting clinical risk of OC, heterozygote models with the rs1544410 (BsmI) polymorphism is likely the best genetic model for detecting the risk of OC in Caucasian patients.
|
30059751 |
2018 |
|
rs1801200
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, no significant association between allelic, dominant, codominant and recessive models of HER2 rs1801200 (V655I) and ovarian cancer was found (<i>p</i> > 0.05).
|
29535531 |
2018 |
|
rs1836724
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data indicated that the ERBB4 rs1836724 polymorphism was associated with the survival of ovarian cancer.
|
29125883 |
2018 |
|
rs186724
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Firstly, individuals carried ERBB4 rs186724 GG genotype had poorer overall survival compared with those carried CC/CT genotypes in ovarian cancer, while the participants with rs1836724 GA genotype had the same overall survival with that in participants with rs1836724 AA genotype in accordance with the result of Cox regression and Kaplan-Meier analyses.
|
29125883 |
2018 |
|
rs1899663
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HOTAIR rs4759314 increased susceptibility to BC, CC, and OC in some patients; rs029778 and rs1899663 also increased susceptibility to some extent.
|
30484890 |
2018 |
|
rs1989839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CONCLUSIONS Polymorphisms of the RASSF1A gene, most significantly the CT genotype of rs1989839, might play a role in the development and prognosis of ovarian cancer in women in Southern China.
|
29670073 |
2018 |
|
rs2227982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PD-1 rs2227982 C>T and PD-L1 rs4143815 C>G polymorphisms increased the risk for ovarian cancer</span>.
|
29171986 |
2018 |
|
rs4143815
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PD-1 rs2227982 C>T and PD-L1 rs4143815 C>G polymorphisms increased the risk for ovarian cancer.
|
29171986 |
2018 |
|
rs4759314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HOTAIR rs4759314 increased susceptibility to BC, CC, and OC in some patients; rs029778 and rs1899663 also increased susceptibility to some extent.
|
30484890 |
2018 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype.
|
29247577 |
2018 |