|
rs10069690
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A splicing variant in TERT, rs10069690, showed a statistically significant interaction with ET use for risk of serous ovarian cancer (p<sub>int</sub> = 0.013).
|
27420401 |
2016 |
|
rs10069690
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
|
28346442 |
2017 |
|
rs10088218
|
|
|
0.710 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs10088218
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
23535730 |
2013 |
|
rs10088218
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
|
20852632 |
2010 |
|
rs10098821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs1011970
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
|
27197191 |
2016 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that MCP-1 rs1024611A/G and rs3760396C/G polymorphisms are associated with increased susceptibility to ovarian cancer, in which rs1024611A/G may increase serum level of MCP-1 in the Chinese population.
|
25289731 |
2015 |
|
rs10260419
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.
|
30898391 |
2019 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008).
|
25591549 |
2015 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The rs1042522 polymorphism was not overall associated with o</span>varian cancer risk.
|
25060098 |
2014 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian cancer risk than rs1042522 in TP53.
|
23192612 |
2013 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Meta-analysis shows significant association of the TP53 Arg72Pro with ovarian cancer risk.
|
21952824 |
2012 |
|
rs1042838
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Five haplotypes occurred with greater than 5% frequency, and the haplotype carrying the V</span>660L variant had a significant association with ovarian cancer (odds ratio = 0.76, 95% confidence interval: 0.62, 0.92).
|
15718480 |
2005 |
|
rs1042838
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the two polymorphisms of PGR, Alu insertion and Val660Leu, may contribute to ovarian cancer susceptibility as low-penetrance risk factors.
|
25228088 |
2015 |
|
rs1042838
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No significant association between progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of ovarian cancer.
|
11323389 |
2001 |
|
rs1045485
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the present study we investigate the relevance of RAD51 -135C > G, TP53 R72P, NQO1*2 and CASP8 D302H polymorphisms as potential modifiers of BC and/or OC susceptibility conferred by these mutations.
|
19214744 |
2010 |
|
rs1045485
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The minor allele of CASP8 D302H was significantly associated with a reduced risk of breast cancer (per-allele HR, 0.85; 95% CI, 0.76-0.97; P(trend) = 0.011) and ovarian cancer (per-allele HR, 0.69; 95% CI, 0.53-0.89; P(trend) = 0.004) for BRCA1 but not for BRCA2 mutation carriers.
|
20978178 |
2010 |
|
rs1046428
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped GSTA2_448_C > G (rs2180314), GSTA2_742_A > C (rs6577), GSTM2_-832_T > C (rs638820), GSTO1_-1242_G > A (rs2164624), GSTO1_419_A > C (rs4925), GSTO2_-183_A > G (rs2297235), GSTO2_342_A > G (rs156697), GSTZ1_-4378_A > G (rs1046428), and GSTZ1_94_G > A (rs3177427) by MALDI-TOF MS in the German GENICA breast cancer case-control collection of 1021 cases and 1015 controls and performed breast cancer risk association in general and with respect to the stratifications: menopausal status, family history of breast or ovarian cancer, use of oral contraceptives, use of hormone therapy, body mass index, and smoking as well as histopathological tumor characteristics including hormone receptor status, grade, histology, and node status.
|
19859803 |
2010 |
|
rs104886003
|
|
A |
0.710 |
CausalMutation |
CLINVAR |
PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations.
|
22271473 |
2012 |
|
rs104886003
|
|
A |
0.710 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs104886003
|
|
A |
0.710 |
CausalMutation |
CLINVAR |
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
|
15647370 |
2005 |
|
rs104886003
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We also found that an activating (E545K) Pik3ca mutation, unlike Pten inactivation or Pik3ca H1047R mutation, cannot cooperate with Arid1a loss to promote ovarian cancer development in the mouse.
|
26279473 |
2016 |
|
rs1048943
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Ile462Val status seems to represent a meaningful risk factor for ovarian cancer in Caucasians.
|
22733497 |
2012 |
|
rs1048943
|
|
|
0.030 |
GeneticVariation |
BEFREE |
CYP1A1 Ile462Val is a risk factor for ovarian cancer development.
|
22277800 |
2012 |