rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, our data indicate that the Q/R192 is principally associated with both CAD and ischemic stroke in Japanese.
|
10729395 |
2000 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The salt stimulation property of serum paraoxonase (PON1) could be a valuable factor in evaluating the enzyme status in ischemic stroke: the role of activity-determined PON1 192Q/R phenotypes.
|
24433930 |
2014 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Individuals who carry the rs662_A allele may benefit to a greater extent from intake of vegetables and thus be more effectively protected from ischemic stroke, whereas carriers of the G allele may still remain at greater risk for ischemic stroke due to their genetic backgrounds even when they consume a high level of vegetables.
|
29215590 |
2017 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Existing evidence indicates that the Q192R polymorphism (the R allele and RR genotype) is associated with an increased risk of ischaemic stroke in the general population.
|
22631428 |
2013 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The overall analysis shows a significant contribution of the rs662 variant to IS risk.
|
26978533 |
2017 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In agreement with observations in coronary artery disease, PON1 rs662 appears to be associated with a small increase in the risk of ischemic stroke.
|
20856122 |
2010 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The purpose of the study was to analyze PON1 192 Q/R polymorphism and the enzyme activities in ischemic stroke.
|
23054002 |
2012 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Paraoxonase 192 Gln-->Arg polymorphism: an independent risk factor for nonfatal arterial ischemic stroke among young adults.
|
12052975 |
2002 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interaction of folate intake and the paraoxonase Q192R polymorphism with risk of incident coronary heart disease and ischemic stroke: the atherosclerosis risk in communities study.
|
21982484 |
2011 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we aimed to determine the importance of -107T/C, 192Q/R and 55L/M polymorphisms of PON1 gene and three PON1 activities (diazoxonase, paraoxonase, arylesterase) as risk factors for ischemic stroke.
|
19902425 |
2009 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis proved that PON1 rs854560 polymorphism could be used to identify individual with elevated susceptibility to IS, whereas rs662 polymorphism could be used to identify individual with elevated susceptibility to CAD.
|
31302193 |
2019 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the significance of the Q192R and M55L polymorphisms of the PON1 gene and the C311S polymorphism of the PON2 gene in different etiologies of ischemic stroke.
|
17406108 |
2007 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis demonstrated a significant nominal association between rs662 and ischemic stroke, but there was no evidence of an association between rs662 and ischemic stroke risk in a single site association study.
|
23356507 |
2013 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischemic stroke.
|
17920578 |
2008 |
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In this study, we aimed to determine the importance of -107T/C, 192Q/R and 55L/M polymorphisms of PON1 gene and three PON1 activities (diazoxonase, paraoxonase, arylesterase) as risk factors for ischemic stroke.
|
19902425 |
2009 |
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Two of the 11 SNPs (rs662 and rs854560) were contextualized in a meta-analysis of ischemic stroke.
|
23356507 |
2013 |
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Overall, no significant association was found between L55M and IS when all studies were pooled nor by subgroup analysis by ethnicity.
|
26978533 |
2017 |
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We studied the significance of the Q192R and M55L polymorphisms of the PON1 gene and the C311S polymorphism of the PON2 gene in different etiologies of ischemic stroke.
|
17406108 |
2007 |
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We performed a meta-analysis of published studies investigating the association between ischemic stroke and two nonsynonymous PON1 polymorphisms, rs662 (p.Q192R) and rs854560 (p.L55M) in humans.
|
20856122 |
2010 |
rs854560
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis proved that PON1 rs854560 polymorphism could be used to identify individual with elevated susceptibility to IS, whereas rs662 polymorphism could be used to identify individual with elevated susceptibility to CAD.
|
31302193 |
2019 |
rs705381
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of rs705381 (-162) in the promoter region of PON1 was significantly associated with total stroke (P(adjusted) = 0.0007, OR = 0.57 [95% CI = 0.41-0.79]) and ischemic stroke (P(adjusted) = 0.0017, OR = 0.54 [95% CI = 0.37-0.79]) when analyzed using a dominant model, but was not associated with hemorrhagic stroke.
|
23356507 |
2013 |