We found no association of the <i>ALOX5AP</i> rs10507391 (OR=1.03 for A allele vs T allele; 95% CI: 0.93-1.14; <i>P</i>=0.557), rs4769874 (OR=1.13 for A allele vs G allele; 95% CI: 1.00-1.28; <i>P</i>=0.050), rs9551963 (OR=1.03 for A allele vs C allele; 95% CI: 0.96-1.11; <i>P</i>=0.372), rs17222814 (OR=1.09 for A allele vs G allele; 95% CI: 0.96-1.24; <i>P</i>=0.195), rs17222919 (OR=0.89 for G allele vs T allele; 95% CI: 0.75-1.06; <i>P</i>=0.175), and rs4073259 (OR=1.20 for A allele vs G allele; 95% CI: 1.00-1.45; <i>P</i>=0.056) polymorphisms with IS risk.
The interaction between rs10507391 and rs776746 increases the susceptibility to ischemic stroke and is associated with atherothrombotic events in stroke patients.