We found no association of the <i>ALOX5AP</i> rs10507391 (OR=1.03 for A allele vs T allele; 95% CI: 0.93-1.14; <i>P</i>=0.557), rs4769874 (OR=1.13 for A allele vs G allele; 95% CI: 1.00-1.28; <i>P</i>=0.050), rs9551963 (OR=1.03 for A allele vs C allele; 95% CI: 0.96-1.11; <i>P</i>=0.372), rs17222814 (OR=1.09 for A allele vs G allele; 95% CI: 0.96-1.24; <i>P</i>=0.195), rs17222919 (OR=0.89 for G allele vs T allele; 95% CI: 0.75-1.06; <i>P</i>=0.175), and rs4073259 (OR=1.20 for A allele vs G allele; 95% CI: 1.00-1.45; <i>P</i>=0.056) polymorphisms with IS risk.
Our study provides evidence that the promoter single nucleotide polymorphism (SNP) rs17222919 is a potential genetic protective factor for IS in the Chinese Han population.
To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are associated with intracerebral hemorrhage (ICH) and ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (rs434473, Asn322Ser), ALOX5 (rs2228064, Thr90Thr), ALOX5AP (rs17222919, -1316T/G), PTGES (rs7872802, -404A/G), PTGIS (rs5628, Leu256Leu), PTGS1 (rs3842788, Gln41Gln) and PTGS2 (rs5275, 3'UTR).