Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Our meta-analysis establishes that the G894T</span> and 4b/a polymorphisms of eNOS gene are significantly associated with the risk of IS. 28084234

2019

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The findings of the present study suggest that polymorphism in G894T position of eNOS gene might be a risk factor for IS mainly for LVD stroke subtype in North Indian population. 27168380

2016

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The study concluded that SNP G894T variant is associated with ischemic stroke and might contribute to ischemic stroke susceptibility in North Indians. 26994413

2015

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Two NOS3 SNP [894G/T and 2479G/A] variants and NOx levels are associated with ischemic stroke in young Asian Indians. 24986538

2014

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE For eNOS G894T polymorphism, the results indicated that TT genotype was significantly associated with increased risk of IS incidence compared to G allele (OR and 95 % CI 1.25 (1.09-1.42) for TT vs. GT+GG, P < 0.001). 24573998

2014

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE In the present study, we aimed to investigate the relationship between endothelial nitric oxide synthase 3 (NOS3) G894T, T-786C, and intron 4 variable number of tandem repeat (VNTR) variants, alone or in combination, and the risk of incidence of ischemic stroke in the Turkish population. 25321404

2014

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Our comprehensive meta-analysis ascertains that the G894T, 4b/a, and T786C polymorphisms are associated with ischemic stroke risk in Asians. 23560937

2013

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The meta-analysis indicated that eNOS gene 4b/a, T-786C, G894T polymorphism might be associated with IS. 23544143

2013

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE For G894T and 4b/a, a significant association of 894T allele and 4a allele with increased risk of IS was found in Asians (TT+GT vs. GG: p<0.00001, OR=1.60, 95% CI=1.38-1.79, Pheterogeneity=0.11; aa+ba vs. bb: P<0.00001, OR=1.60, 95% CI=1.30-1.97, Pheterogeneity=0.02), but not in Caucasians (TT+GT vs. GG: P=0.60, OR=0.94, 95% CI=0.75-1.19, Pheterogeneity=0.002; aa+ba vs. bb: P=0.13, OR=0.81, 95% CI=0.62-1.06, Pheterogeneity=0.63). 23845784

2013

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Previous studies have shown that ischemic stroke (IS) was closely associated with the Glu298Asp polymorphism in the eNOS gene and the 677C-T (Ala→Val) polymorphism in methylenetetrahydrofolate reductase (MTHRF) gene. 22940147

2012

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Endothelial nitric oxide synthase Glu298Asp, 4b/a, and -786T>C gene polymorphisms and the risk of ischemic stroke. 19804474

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The aim of this study was to investigate the association of T-786C, G894T and 4a/b polymorphisms in the endothelial nitric oxide synthase (eNOS) gene with early-onset ischemic stroke in South Indians. 20037257

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Further research is warranted to clarify the relevance of G894T polymorphisms to ischemic stroke. 19447301

2009

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The results suggested the lack of the association between the Glu298Asp gene polymorphism and ischemic stroke or subtypes of ischemic stroke in the Turkish population. 18781402

2009

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Three polymorphisms of the eNOS gene (-922A/G, -786T/C, 894G/T) were determined by using TaqMan SNP genotyping assay in 309 Chinese patients with IS and 309 Chinese controls. 18396156

2008

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The association of polymorphisms in the nitric oxide synthase 3 (NOS3) gene (T-786C, variable number tandem repeats 4A/B/C, and G894T) and in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T) with acute ischemic stroke have been reported. 19049547

2008

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE For one of these SNPs, the glu298asp polymorphism in the nitric oxide synthase 3 gene, an association with ischemic stroke was replicated in the second study and also in a combined analysis of both studies. 17165044

2007

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE We are unable to confirm previous reports of an association of the intron 4a or the G894T alleles with ischemic stroke. 18070351

2007

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE However, it is the interplay of both environmental and common genetic factors [such as the Leiden V, methylenetetrahydrofolate reductase C677T, apolipopotein E 4, endothelial nitric oxide synthase G894T, angiotensin-converting enzyme I/D and angiotensin II type 1 receptor A1166C mutations and polymorphisms] that leads to the development of ischaemic stroke. 16787209

2006

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The eNOS G894T or eNOS 894TT genotypes in combination with the MTHFR 677TT or ACE D/D genotype increases the risk of ischaemic stroke. 15595935

2005