Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE In summary, this meta-analysis proved that PON1 rs854560 polymorphism could be used to identify individual with elevated susceptibility to IS, whereas rs662 polymorphism could be used to identify individual with elevated susceptibility to CAD. 31302193

2019

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE Individuals who carry the rs662_A allele may benefit to a greater extent from intake of vegetables and thus be more effectively protected from ischemic stroke, whereas carriers of the G allele may still remain at greater risk for ischemic stroke due to their genetic backgrounds even when they consume a high level of vegetables. 29215590

2017

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE The overall analysis shows a significant contribution of the rs662 variant to IS risk. 26978533

2017

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE The salt stimulation property of serum paraoxonase (PON1) could be a valuable factor in evaluating the enzyme status in ischemic stroke: the role of activity-determined PON1 192Q/R phenotypes. 24433930

2014

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE Existing evidence indicates that the Q192R polymorphism (the R allele and RR genotype) is associated with an increased risk of ischaemic stroke in the general population. 22631428

2013

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE Meta-analysis demonstrated a significant nominal association between rs662 and ischemic stroke, but there was no evidence of an association between rs662 and ischemic stroke risk in a single site association study. 23356507

2013

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE The purpose of the study was to analyze PON1 192 Q/R polymorphism and the enzyme activities in ischemic stroke. 23054002

2012

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE Interaction of folate intake and the paraoxonase Q192R polymorphism with risk of incident coronary heart disease and ischemic stroke: the atherosclerosis risk in communities study. 21982484

2011

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE In agreement with observations in coronary artery disease, PON1 rs662 appears to be associated with a small increase in the risk of ischemic stroke. 20856122

2010

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE In this study, we aimed to determine the importance of -107T/C, 192Q/R and 55L/M polymorphisms of PON1 gene and three PON1 activities (diazoxonase, paraoxonase, arylesterase) as risk factors for ischemic stroke. 19902425

2009

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischemic stroke. 17920578

2008

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE We studied the significance of the Q192R and M55L polymorphisms of the PON1 gene and the C311S polymorphism of the PON2 gene in different etiologies of ischemic stroke. 17406108

2007

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE Paraoxonase 192 Gln-->Arg polymorphism: an independent risk factor for nonfatal arterial ischemic stroke among young adults. 12052975

2002

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE Taken together, our data indicate that the Q/R192 is principally associated with both CAD and ischemic stroke in Japanese. 10729395

2000