rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Clinicopathologic heterogeneity in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) due to microtubule-associated protein tau (MAPT) p.P301L mutation, including a patient with globular glial tauopathy.
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27859539 |
2017 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Lastly, we have demonstrated that tau is phosphorylated on Tyr-18 in the tau P301L mouse model for tauopathy (JNPL3).
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16115884 |
2005 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Because the mutations (V337M, P301L) are associated with genetic tauopathies, these results suggest that a factor in disease etiology of genetic tauopathies and other dementias with altered tau is a greater abundance of tau in the cytoplasm due to decreased binding to microtubules.
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11170176 |
2001 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
We evaluated two structurally similar natural compounds, morin and resveratrol, for treating tauopathy in JNPL3 P301L mutant human tau overexpressing mice.
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30479844 |
2018 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy.
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28456717 |
2017 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Interestingly, FTLD-tau cases with MAPT mutations had similar patterns and severity of neuropathological features to sporadic FTLD-tau subtypes and could be classified into: Pick's disease (K257T), corticobasal degeneration (S305S, IVS10+16, R406W), progressive supranuclear palsy (S305S) or globular glial tauopathy (P301L, IVS10+16).
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29253099 |
2018 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Here we used the non-invasive, Manganese-Enhanced Magnetic Resonance Imaging technique (MEMRI), to study for the first time a pure model of tauopathy, the JNPL3 transgenic mouse line, which overexpresses a mutated (P301L) form of the human tau protein.
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22960250 |
2013 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Together, our results show that expression of the P301L mutation in mice causes neuronal lesions that are similar to those seen in human tauopathies.
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11013246 |
2001 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Thus, Pin1 has opposite effects on the tauopathy</span> p</span>henotype depending on whether the tau is WT or a P301L mu</span>tant, indicating the need for disease-specific therapies for tauopathies.
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18431510 |
2008 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
The TauP301L mouse expresses P301L tau under the control of a prion promoter in both neurons and astrocytes, reminiscent of some human tauopathies.
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28869476 |
2017 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
In the present study, we employed a somatic cell gene transfer technique to create a rodent model of tauopathy by injecting a recombinant adeno-associated viral vector with a mutated human tau gene (P301L) into the hippocampus of adult rats.
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22561128 |
2012 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
In addition to classic markers of tauopathy, significant neuroinflammation and extensive gliosis were detected in AAV1-Tau(P301L) mice.
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26276810 |
2015 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
The tauopathy in P301L and G272V does not appear to be associated with an evident increase in CSF levels of Ptau-181 in FTD patients with these tau mutations, in contrast with findings in patients with AD.
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12975285 |
2003 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein.
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12127682 |
2002 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
The JNPL3 mice express human tau proteins bearing a P301L mutation, which mimics the neurodegenerative process observed in humans with tauopathy.
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22975846 |
2012 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Overall, our genetically matched mice have revealed that 4R NM hTau over expression is pathogenic in a manner distinct from classical aging-related tauopathy, underlining the importance of assaying the effects of transgenic disease-related proteins at appropriate stages in life.<b>SIGNIFICANCE STATEMENT</b>Due to differences in creation of transgenic lines, the pathological properties the P301L mutation confers to the tau protein <i>in vivo</i> have remained elusive, perhaps contributing to the lack of disease-modifying therapies for tauopathies.
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31685653 |
2020 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
In this study, we found that aged Tg mice of both sexes expressing human tau proteins harboring a pathogenic P301L <i>MAPT</i> mutation labeled with green fluorescent protein (T40PL-GFP Tg mouse line) exhibited hyperphosphorylated tau mislocalized to the somatodentritic domain of neurons, but these mice did not develop <i>de novo</i> insoluble tau aggregates, which are characteristic of human AD and related tauopathies.
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28986461 |
2017 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Here, we showed that Aβ-induced tau hyperphosphorylation and neurodegeneration, including tau phosphorylation, synaptic disorder and neuronal loss, in the brains of both male wild-type (Wt) mice and male P301L transgenic mice (a mouse model of human tauopathy) were alleviated by genetic knockout of p75<sup>NTR</sup> in the both mouse models.
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31394202 |
2019 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.
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24623856 |
2014 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
Here, we found that the BDNF level was reduced in the serum and brain of AD patients and P301L transgenic mice (a mouse model of tauopathy).
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27701410 |
2016 |
rs63751273
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0.100 |
GeneticVariation |
BEFREE |
These properties were similar to the biochemical features of P301L mutated human tau in a mouse model of tauopathy.
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29772786 |
2018 |
rs63751438
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0.100 |
GeneticVariation |
BEFREE |
α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice.
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29126071 |
2018 |
rs63751438
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0.100 |
GeneticVariation |
BEFREE |
To explore this interaction in vivo, we crossed a well-characterized human P301S-tau transgenic mouse model of tauopathy with human G2019S-LRRK2 transgenic mice or LRRK2 knockout (KO) mice.
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29088368 |
2018 |
rs63751438
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0.100 |
GeneticVariation |
BEFREE |
S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy.
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30696811 |
2019 |
rs63751438
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0.100 |
GeneticVariation |
BEFREE |
We further demonstrate that peripheral administration of the same antibodies in the more rapidly progressive P301S tauopathy model not only reduces Tau pathology quantitated by biochemical assays and immunohistochemistry, but also significantly delays the onset of motor function decline and weight loss.
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21841002 |
2011 |