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rs567534295
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analyses performed under logistic model, linear mixed model, and model incorporating correlations identified nine significant associations with three gynecologic diseases including four novel findings (rs79219469:C > T, LINC02183, P = 3.3 × 10<sup>-8</sup> and rs567534295:C > T, BRCA1, P = 3.1 × 10<sup>-8</sup> with OC, rs150806792:C > T, INS-IGF2, P = 4.9 × 10<sup>-8</sup> and rs140991990:A > G, SOX9, P = 3.3 × 10<sup>-8</sup> with UCC).
|
31488892 |
2020 |
|
rs80357268
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRCA1, p.(Val1833Met) is possibly a disease-associated variant, supported by a likelihood ratio of 1.88, while a correlation to ovarian cancer is suspected.
|
31447071 |
2019 |
|
rs12373237
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CC homozygous mutation of rs12373237 was highly correlated with the onset of ovarian cancer (OR=4.333, P=0.028).
|
31402958 |
2019 |
|
rs2699887
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interaction between PIK3CA rs2699887 SNP and age, number of liveborn, tobacco, alcohol, a family history of ovarian cancer and other factors are associated with ovarian cancer risk.
|
31288947 |
2019 |
|
rs3976507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interaction between PIK3CA rs3976507 and rs6443626 loci, and factors such as BMI, number of liveborn, tobacco, alcohol, and family history of ovarian cancer are associated with ovarian cancer risk.
|
31288947 |
2019 |
|
rs6443626
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interaction between PIK3CA rs3976507 and rs6443626 loci, and factors such as BMI, number of liveborn, tobacco, alcohol, and family history of ovarian cancer are associated with ovarian cancer risk.
|
31288947 |
2019 |
|
rs3020450
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To investigate the correlation between the polymorphism of estrogen receptor β gene (ESR2) rs3020450 and cancer susceptibility, and explore the epidemiological significance and the effect of ESR2 expression levels on the prognosis of ovarian cancer.
|
31200086 |
2019 |
|
rs1051740
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Overall results demonstrated that the association between <i>EPHX1</i> polymorphism rs1051740</span> and ovar</span>ian cancer risk had no statistical significance either in total analysis or in subgroup analyses by ethnicity and source of control.
|
31174441 |
2019 |
|
rs876658657
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Correction: The hMLH1 -93G>A Polymorphism and Risk of Ovarian Cancer in the Chinese Population.
|
31150525 |
2019 |
|
rs3212986
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ERCC1 rs3212986 (C/A) polymorphisms posed an increased risk for breast and ovarian cancer as whole (A vs C: OR = 1.12, 95% CI = 1.01-1.25; AA + CA vs CC: OR = 1.11, 95% CI = 1.02-1.22), and presented especially higher risk for ovarian cancer (A vs C: OR = 1.31, 95% CI = 1.05-1.63; AA vs CA + CC: OR = 1.66, 95% CI = 1.12-2.47; AA vs CC: OR = 1.72, 95% CI = 1.12-2.64).
|
31081240 |
2019 |
|
rs200640585
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PMS2 germline mutation c.943C>T (p.Arg315*)-induced Lynch syndrome-associated ovarian cancer.
|
31056861 |
2019 |
|
rs587778617
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PMS2 germline mutation c.943C>T (p.Arg315*)-induced Lynch syndrome-associated ovarian cancer.
|
31056861 |
2019 |
|
rs79722116
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, two non-synonymous SNPs rs201407189 (c.973G>A, p.A325T) and rs1800367 (c.1345G>A, p.V449M), and two synonymous SNPs rs55719336 (c.816C>T, p.I272I) and rs79722116 (c.1407G>A, p.T469T) were identified in FBOC patients.
|
30967997 |
2019 |
|
rs80356897
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, two non-synonymous SNPs rs201407189 (c.973G>A, p.A325T) and rs1800367 (c.1345G>A, p.V449M), and two synonymous SNPs rs55719336 (c.816C>T, p.I272I) and rs79722116 (c.1407G>A, p.T469T) were identified in FBOC patients.
|
30967997 |
2019 |
|
rs137853011
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This karyotype phenotype was not observed in other tested tissues or in an ovarian cancer patient with a different homozygous missense mutation in <i>CHEK2</i> (c.1283C>T; p.Ser428Phe).
|
30858171 |
2019 |
|
rs920778
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association between the expression of rs920778 and BC, CC, and OC susceptibility was not clear (alleles T/C: OR = 1.28 [95% CI, 0.87-1.89]; in codominant model: CT/CC OR = 1.10, [95% CI, 0.71-1.71], TT/CC OR = 1.29 [95% CI, 0.59-2.80]; dominant model: TC + TT/CC OR = 1.16, [95% CI, 0.73-1.86]; and recessive model: TT/TC + CC OR = 1.43, [95% CI, 0.83-2.47]).
|
30484890 |
2018 |
|
rs1899663
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HOTAIR rs4759314 increased susceptibility to BC, CC, and OC in some patients; rs029778 and rs1899663 also increased susceptibility to some extent.
|
30484890 |
2018 |
|
rs4759314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HOTAIR rs4759314 increased susceptibility to BC, CC, and OC in some patients; rs029778 and rs1899663 also increased susceptibility to some extent.
|
30484890 |
2018 |
|
rs874945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs12826786, rs7958904, and rs874945 did not correlate with an effect on patient susceptibility to BC, CC, and OC.
|
30484890 |
2018 |
|
rs25487
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study indicated that XRCC1 Arg194Trp, Arg280His, and Arg399Gln did not affect OS after platinum-based chemotherapy in OC patients.
|
30407287 |
2018 |
|
rs495139
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In expression quantitative trait locus (eQTL) analysis, the rs495139 allele was positively associated with ENOSF1 mRNA expression in normal tissues of the gastrointestinal system, particularly esophageal mucosa (<i>r</i> = 0.51, <i>p</i> = 1.7 × 10<sup>-28</sup>), and nonsignificantly in five MOC tumors.
|
30134598 |
2018 |
|
rs2228570
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The homozygote model with the rs2228570 (FokI) polymorphism model appeared to detect the risk of OC in all cases, whereas the heterozygote model with the rs1544410 (BsmI) polymorphism seemed to detect the risk of OC in Caucasian patients.
|
30059751 |
2018 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, for detecting clinical risk of OC, heterozygote models with the rs1544410 (BsmI) polymorphism is likely the best genetic model for detecting the risk of OC in Caucasian patients.
|
30059751 |
2018 |
|
rs1695
|
|
|
0.030 |
GeneticVariation |
BEFREE |
<i>GSTP1</i> rs1695 is associated with both hematological toxicity and prognosis of ovarian cancer treated with paclitaxel plus carboplatin combination chemotherapy: a comprehensive analysis using targeted resequencing of 100 pharmacogenes.
|
30038720 |
2018 |
|
rs1136905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We established that <i>TP53</i> "hotspot" mutations (c.659A>G; p.Y220C and c.733G>A; p.G245S) expressed by two different patients' tumors were both immunogenic in the context of HLA-DRB3*02:02.<b>Conclusions:</b> Mutation-reactive T cells infiltrated ovarian cancer metastases at sufficient frequencies to warrant their investigation as adoptive cell therapy.
|
29853601 |
2018 |