|
rs28897672
|
|
|
0.730 |
GeneticVariation |
BEFREE |
The risk for breast cancer was 42% higher among first degree relatives of carriers of the C61G missense mutation compared to other mutations (HR = 1.42; p = 0.10) and the risk for ovarian cancer was lower than average (OR = 0.26; p = 0.03).
|
16227521 |
2006 |
|
rs28897672
|
|
|
0.730 |
GeneticVariation |
BEFREE |
We identified a founder mutation (4153delA, 5382insC or C61G) in 6% of 235 unselected cases of breast cancer and in 19% of 43 unselected cases of ovarian cancer.
|
20345474 |
2010 |
|
rs28897672
|
|
|
0.730 |
GeneticVariation |
BEFREE |
While the Cys61Gly mutation appeared underrepresented in ovarian cancer as compared with breast cancer cases from the same population (p = 0.01), the 4153delA mutation made a higher contribution to ovarian cancer than to breast cancer (p < 0.01).
|
20569256 |
2010 |
|
rs1801155
|
|
|
0.720 |
GeneticVariation |
BEFREE |
To determine whether the excess of colon cancer in some breast-ovarian cancer families is related to the I1307K mutation, we evaluated 264 Ashkenazi Jews from 158 families.
|
9407954 |
1997 |
|
rs1801155
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In the Ashkenazi Jewish population, the I1307K allele is unlikely to increase the risk of ovarian cancer or of cancer in general.
|
9679945 |
1998 |
|
rs2072590
|
|
|
0.720 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs2072590
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The OC risk-associated SNP rs2072590 lies in non-coding DNA downstream of <i>HOXD3</i> and upstream of <i>HOXD1</i>, and it tags SNPs in the <i>HOXD3</i> 3' UTR.
|
29262571 |
2017 |
|
rs3814113
|
|
|
0.720 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs3814113
|
|
|
0.720 |
GeneticVariation |
BEFREE |
A genome-wide association study recently identified an association between the rare allele of the single-nucleotide polymorphism (SNP) rs3814113 (ie, the C allele) at 9p22.2 and decreased risk of ovarian cancer for women in the general population.
|
21169536 |
2011 |
|
rs10088218
|
|
|
0.710 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs121913279
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We also found that an activating (E545K) Pik3ca mutation, unlike Pten inactivation or Pik3ca H1047R mutation, cannot cooperate with Arid1a loss to promote ovarian cancer development in the mouse.
|
26279473 |
2016 |
|
rs17879961
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The association between the I157T missense variant was then confirmed in a second sample of Russian patients with borderline ovarian cancers</span> (OR = 2.7; P = 0.06).
|
16828850 |
2006 |
|
rs2363956
|
|
|
0.710 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs2665390
|
|
|
0.710 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs1217691063
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The C677T polymorphism of the MTHFR gene is associated with the susceptibility of ovarian cancer in Asian population, suggesting that TT genotype may serve as a risk factor of ovarian cancer among Asian but not Caucasians.
|
24720627 |
2014 |
|
rs1217691063
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Our analysis indicated neither folate intake nor MTHFR C677T polymorphism is related to altered susceptibility of ovarian cancer.
|
24129496 |
2013 |
|
rs1217691063
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Overall, we observed no association between either SNP and ovarian cancer risk (pooled C677T p(trend)=0.59 and A1298C p(trend)=0.58).
|
20817226 |
2010 |
|
rs1217691063
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In conclusion, the results of this meta-analysis indicate that the MTHFR C677T and A1298C polymorphisms are not associated with ovarian cancer risk, especially in Caucasians.
|
22810649 |
2012 |
|
rs1217691063
|
|
|
0.070 |
GeneticVariation |
BEFREE |
This meta-analysis supports an association between MTHFR C677T</span> polymorphism and ovarian cancer risk, and there might be a race-specific effect in this association.
|
23329275 |
2013 |
|
rs1217691063
|
|
|
0.070 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism and ovarian cancer risk: a meta-analysis.
|
23098496 |
2012 |
|
rs1217691063
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In conclusion, we observed that the MTHFR C677T polymorphism is associated with the susceptibility and survival of ovarian cancer in Chinese population.
|
22524826 |
2012 |
|
rs113488022
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Genetic analyses have identified BRAF V600E mutations in a subset of ovarian carcinomas.
|
22820660 |
2013 |
|
rs113488022
|
|
|
0.060 |
GeneticVariation |
BEFREE |
One recurrent somatic mutation, p.V600E, is frequently found in several tumor types, such as melanoma, papillary thyroid carcinoma, colon cancer, and ovarian cancer.
|
20735442 |
2011 |
|
rs113488022
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Sustained response to vemurafenib in a low grade serous ovarian cancer with a BRAF V600E mutation.
|
26490654 |
2015 |
|
rs113488022
|
|
|
0.060 |
GeneticVariation |
BEFREE |
BRAF V600E protein was expressed in BM of 42/76 (55.3%) melanomas, 1/15 (6.7%) ovarian cancers, 4/72 (5.5%) colorectal cancers, 1/355 (0.3%) lung cancers, 2/6 thyroid cancers and 1/2 choriocarcinomas.
|
22012135 |
2012 |