|
rs3814113
|
|
|
0.720 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs3814113
|
|
|
0.720 |
GeneticVariation |
BEFREE |
A genome-wide association study recently identified an association between the rare allele of the single-nucleotide polymorphism (SNP) rs3814113 (ie, the C allele) at 9p22.2 and decreased risk of ovarian cancer for women in the general population.
|
21169536 |
2011 |
|
rs3814113
|
|
T |
0.720 |
GeneticVariation |
GWASDB |
The most significant SNP (rs3814113; P = 2.5 x 10(-17)) was genotyped in a further 2,670 ovarian cancer cases and 4,668 controls, confirming its association (combined data odds ratio (OR) = 0.82, 95% confidence interval (CI) 0.79-0.86, P(trend) = 5.1 x 10(-19)).
|
19648919 |
2009 |
|
rs3814113
|
|
|
0.720 |
GeneticVariation |
GWASDB |
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
23535730 |
2013 |
|
rs10810666
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.
|
19648919 |
2009 |
|
rs10962656
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.
|
19648919 |
2009 |
|
rs4445329
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.
|
19648919 |
2009 |
|
rs2660753
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SNP rs2660753 (chromosome 3p12) showed evidence of association with ovarian cancer [per minor allele OR, 1.19; 95% confidence interval (95% CI), 1.04-1.37; P(trend) = 0.012].
|
18974127 |
2008 |
|
rs2660753
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer.
|
21415361 |
2011 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that MCP-1 rs1024611A/G and rs3760396C/G polymorphisms are associated with increased susceptibility to ovarian cancer, in which rs1024611A/G may increase serum level of MCP-1 in the Chinese population.
|
25289731 |
2015 |
|
rs4954956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we found that rs4954956 was associated with increased ovarian cancer risk, particularly for serous ovarian cancer.
|
19304784 |
2009 |
|
rs67397200
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found for the first time that rs67397200 at 19p13.1 was associated with an increased risk of ovarian cancer for BRCA1 (HR, 1.16; 95% CI, 1.05-1.29; P = 3.8 × 10(-4)) and BRCA2 mutation carriers (HR, 1.30; 95% CI, 1.10-1.52; P = 1.8 × 10(-3)).
|
22351618 |
2012 |
|
rs6785617
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Considering a multiple-testing-corrected significance threshold of P < 2.5 × 10(-5), only one other variant, the TNFSF10 SNP rs6785617, was associated significantly with a risk of ovarian cancer (low malignant potential tumors OR, 0.85; 95% CI, 0.79-0.91; P = 0.00002).
|
24272484 |
2014 |
|
rs7313833
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Initially, three SNPs (rs2107425 in MRPL23, rs7313833 in PTHLH, rs3803662 in TNRC9) were weakly associated with ovarian cancer risk and one SNP (rs4954956 in NXPH2) was associated with serous ovarian cancer in non-Hispanic white subjects (P-trend < 0.1).
|
19304784 |
2009 |
|
rs7365052
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs7365052, rs7526063) showed borderline significant inverse associations with ovarian cancer risk; both had very low minor allele frequencies.
|
21629268 |
2011 |
|
rs874945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs12826786, rs7958904, and rs874945 did not correlate with an effect on patient susceptibility to BC, CC, and OC.
|
30484890 |
2018 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The mdr-1 polymorphism G2677T/A in exon 21 correlates with the paclitaxel response in ovarian cancer and may be important for the function of P-glycoprotein and resistance to paclitaxel and provide useful information for individualized therapy.
|
16467099 |
2006 |
|
rs2229109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel.
|
17828752 |
2008 |
|
rs35068177
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs C1236T, G1199T/A, and A1308G were determined using Pyrosequencing in 51 patients with advanced ovarian cancer and correlated to the progression free survival.
|
17828752 |
2008 |
|
rs186724
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Firstly, individuals carried ERBB4 rs186724 GG genotype had poorer overall survival compared with those carried CC/CT genotypes in ovarian cancer, while the participants with rs1836724 GA genotype had the same overall survival with that in participants with rs1836724 AA genotype in accordance with the result of Cox regression and Kaplan-Meier analyses.
|
29125883 |
2018 |
|
rs121434592
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Recently, a somatic mutation in AKT1 (E17K) has been detected in breast, colorectal, lung and ovarian cancers.
|
18504432 |
2008 |
|
rs121434592
|
|
|
0.030 |
GeneticVariation |
BEFREE |
An earlier study discovered an oncogenic AKT1 gene mutation (AKT1 E17K) in breast, colorectal and ovarian cancers.
|
18392055 |
2008 |
|
rs121434592
|
|
|
0.030 |
GeneticVariation |
BEFREE |
They described a novel point mutation (E17K) in the pleckstrin homology domain (PHD) of the AKT1 gene in human breast, colorectal and ovarian cancers, and demonstrated that it induces leukemia in mice.
|
17921701 |
2007 |
|
rs387906659
|
|
|
0.020 |
GeneticVariation |
BEFREE |
An earlier study discovered an oncogenic AKT1 gene mutation (AKT1 E17K) in breast, colorectal and ovarian cancers.
|
18392055 |
2008 |
|
rs387906659
|
|
|
0.020 |
GeneticVariation |
BEFREE |
They described a novel point mutation (E17K) in the pleckstrin homology domain (PHD) of the AKT1 gene in human breast, colorectal and ovarian cancers, and demonstrated that it induces leukemia in mice.
|
17921701 |
2007 |