To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
The OC risk-associated SNP rs2072590 lies in non-coding DNA downstream of <i>HOXD3</i> and upstream of <i>HOXD1</i>, and it tags SNPs in the <i>HOXD3</i> 3' UTR.