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rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype.
|
29247577 |
2018 |
|
rs771386507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We established that <i>TP53</i> "hotspot" mutations (c.659A>G; p.Y220C and c.733G>A; p.G245S) expressed by two different patients' tumors were both immunogenic in the context of HLA-DRB3*02:02.<b>Conclusions:</b> Mutation-reactive T cells infiltrated ovarian cancer metastases at sufficient frequencies to warrant their investigation as adoptive cell therapy.
|
29853601 |
2018 |
|
rs874945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs12826786, rs7958904, and rs874945 did not correlate with an effect on patient susceptibility to BC, CC, and OC.
|
30484890 |
2018 |
|
rs11651755
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As rs11651755 in HNF1B modified both the ovarian cancer risk and also the risk for endometriosis, HNF1B may be causally involved in the pathogenetic pathway leading from endometriosis to ovarian cancer.
|
28214017 |
2017 |
|
rs1222213359
|
|
|
0.010 |
GeneticVariation |
BEFREE |
None of the five genetic models suggested a significant association between -1154G/A and ovarian cancer risk in the entire study population, or between +936C/T and risk in Asian or Chinese participants.
|
29069849 |
2017 |
|
rs13281615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no significant association was observed between rs13281615 and ovarian cancer.
|
28430593 |
2017 |
|
rs1444192401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A direct sequencing analysis of p53 revealed a p.V173M mutation in exon 5 in both the breast tumor and the ovarian cancer.
|
28662703 |
2017 |
|
rs2228026
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant SNP was TEP1: rs2228026 with participants carrying at least one variant allele exhibiting a 3.28-fold (95% CI: 1.72-6.29; P < 0.001, Q = 0.028) increased ovarian cancer risk, which remained significant after multiple testing adjusting.
|
28233473 |
2017 |
|
rs238406
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The R156R (C to A, rs238406) polymorphism of ERCC2 gene was investigated by the PCR-RFLP technique in 400 patients with ovarian carcinoma and 400 age- and sex matched non-cancer controls.
|
27888704 |
2017 |
|
rs540432391
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The occurrence of two studied polymorphisms, rs7260002 and rs540432391 present in the 5' upstream region of the chorionic gonadotropin (CG) gene were associated with an increased risk of ovarian cancer.
|
28355589 |
2017 |
|
rs6983267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Summarily, this study suggested that 8q24 rs6983267 may contribute to the susceptibility of ovarian cancer in premenopausal Han Chinese women, supporting the pleiotropy of 8q24 in carcinogenesis.
|
28430593 |
2017 |
|
rs7246045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed Central European females diagnosed with ovarian cancer (n=95) and controls (n=76) for the occurrence of at least one of three polymorphisms (rs7260002, rs7246045, rs540432391) and their impact on cancer risk.
|
28355589 |
2017 |
|
rs7260002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The occurrence of two studied polymorphisms, rs7260002 and rs540432391 present in the 5' upstream region of the chorionic gonadotropin (CG) gene were associated with an increased risk of ovarian cancer.
|
28355589 |
2017 |
|
rs767796996
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer.
|
27622768 |
2017 |
|
rs851797
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant association of the <i>EXO1</i> rs851797 polymorphism with clinical outcome of ovarian cancer.
|
29042795 |
2017 |
|
rs876660754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A direct sequencing analysis of p53 revealed a p.V173M mutation in exon 5 in both the breast tumor and the ovarian cancer.
|
28662703 |
2017 |
|
rs904571820
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A direct sequencing analysis of p53 revealed a p.V173M mutation in exon 5 in both the breast tumor and the ovarian cancer.
|
28662703 |
2017 |
|
rs104886003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that an activating (E545K) Pik3ca mutation, unlike Pten inactivation or Pik3ca H1047R mutation, cannot cooperate with Arid1a loss to promote ovarian cancer development in the mouse.
|
26279473 |
2016 |
|
rs10505477
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Long non-coding RNA (lncRNA) CASC8 rs10505477 polymorphism has been identified to be related to risk of many kinds of cancers, such as colorectal cancer, gastric cancer, and invasive ovarian cancer, and it may be involved in the prognosis of gastric cancer patients who have received platinum-based chemotherapy after surgical treatment.
|
27249003 |
2016 |
|
rs1057519865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A somatic missense mutation in the forkhead box L2 (FOXL2) gene (C134W) is unique to adult GCT, and absent in other ovarian cancers.
|
26791928 |
2016 |
|
rs1458766475
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated the association of PPARG Pro12Ala, IL6-174G/C, E-selectin S128R, NFKB1-94 ins/del, NFKBIA-826C/T, and ICAM-1 K469E polymorphisms with ovarian cancer risk in a Chinese population.
|
25659662 |
2016 |
|
rs1469713
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3).
|
27432226 |
2016 |
|
rs153109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Disease type-stratified subgroup analysis yielded increased risk of related diseases in IL-27 rs181206 T>C carriers in the allele model in immune thrombocytopenia (ITP), asthma, and esophageal cancer (EC) subgroups (ITP: OR=0.69, 95%CI=0.53~0.88, P=0.004; asthma: OR=0.60, 95%CI=0.41~0.89, P=0.010; EC: OR=0.79, 95%CI=0.64~0.97, P=0.026); and IL-27 rs153109 A>G polymorphism was remarkably associated with the increased risk of related diseases in the allele model in ovarian cancer (OC), systemic lupus erythematosus (SLE), tuberculosis (TB), ulcerative colitis (UC), and chronic obstructive pulmonary disease (COPD) subgroups (all P<0.05).
|
26950245 |
2016 |
|
rs181206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Disease type-stratified subgroup analysis yielded increased risk of related diseases in IL-27 rs181206 T>C carriers in the allele model in immune thrombocytopenia (ITP), asthma, and esophageal cancer (EC) subgroups (ITP: OR=0.69, 95%CI=0.53~0.88, P=0.004; asthma: OR=0.60, 95%CI=0.41~0.89, P=0.010; EC: OR=0.79, 95%CI=0.64~0.97, P=0.026); and IL-27 rs153109 A>G polymorphism was remarkably associated with the increased risk of related diseases in the allele model in ovarian cancer (OC), systemic lupus erythematosus (SLE), tuberculosis (TB), ulcerative colitis (UC), and chronic obstructive pulmonary disease (COPD) subgroups (all P<0.05).
|
26950245 |
2016 |
|
rs200182588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3).
|
27432226 |
2016 |