|
rs397514606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An earlier study discovered an oncogenic AKT1 gene mutation (AKT1 E17K) in breast, colorectal and ovarian cancers.
|
18392055 |
2008 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype.
|
29247577 |
2018 |
|
rs2363956
|
|
T |
0.710 |
GeneticVariation |
GWASDB |
Common variants at 19p13 are associated with susceptibility to ovarian cancer.
|
20852633 |
2010 |
|
rs2363956
|
|
|
0.710 |
GeneticVariation |
BEFREE |
To assess the potential implications of microRNAs in ovarian cancer, we investigated the associations between microRNA expression and seven ovarian cancer risk variants discovered from genome-wide association studies (GWAS), namely, rs3814113 on 9p22.2, rs2072590 on 2q31, rs2665390 on 3q25, rs10088218, rs1516982, rs10098821 on 8q24.21 and rs2363956 on 19p13.
|
22235027 |
2012 |
|
rs1801155
|
|
A |
0.720 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs1801155
|
|
|
0.720 |
GeneticVariation |
BEFREE |
To determine whether the excess of colon cancer in some breast-ovarian cancer families is related to the I1307K mutation, we evaluated 264 Ashkenazi Jews from 158 families.
|
9407954 |
1997 |
|
rs1801155
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In the Ashkenazi Jewish population, the I1307K allele is unlikely to increase the risk of ovarian cancer or of cancer in general.
|
9679945 |
1998 |
|
rs1463038513
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To determine whether the excess of colon cancer in some breast-ovarian cancer families is related to the I1307K mutation, we evaluated 264 Ashkenazi Jews from 158 families.
|
9407954 |
1997 |
|
rs1463038513
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the Ashkenazi Jewish population, the I1307K allele is unlikely to increase the risk of ovarian cancer or of cancer in general.
|
9679945 |
1998 |
|
rs11954856
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study demonstrated significantly increased APC rs11954856 and rs351771 SNP frequencies in Polish women with ovarian cancer.
|
24078348 |
2014 |
|
rs351771
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study demonstrated significantly increased APC rs11954856 and rs351771 SNP frequencies in Polish women with ovarian cancer.
|
24078348 |
2014 |
|
rs459552
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied nine single nucleotide polymorphisms (SNPs) located in CTNNB1 (β-catenin) [rs4533622, rs2953], APC (rs11954856, rs351771, rs459552), and AXIN2 (rs4074947, rs7224837, rs3923087, rs2240308) in women with ovarian cancer without BRCA1/BRCA2 mutations (n = 228) and controls (n = 282).
|
24078348 |
2014 |
|
rs1130409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1130409 polymorphism was significantly associated with a risk for ovarian cancer.
|
24257553 |
2013 |
|
rs1760944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, the rs1760944 polymorphism was not found to be associated with a risk for ovarian cancer.
|
24257553 |
2013 |
|
rs34301344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ARLTS1 mutation Trp149Stop and Cys148Arg have been shown to be associated with familial cancers, but limited information is available regarding the impact of ARLTS1 variants on familial ovarian cancer (OC).
|
19509554 |
2009 |
|
rs3803185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ARLTS1 Cys148Arg revealed a significant association with an increased risk of familial OC compared with both sporadic cases and controls in a dose-dependent manner (P = 0.0031 and 0.012, respectively).
|
19509554 |
2009 |
|
rs755100942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ARLTS1 mutation Trp149Stop and Cys148Arg have been shown to be associated with familial cancers, but limited information is available regarding the impact of ARLTS1 variants on familial ovarian cancer (OC).
|
19509554 |
2009 |
|
rs74315464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008).
|
25591549 |
2015 |
|
rs751039340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008).
|
25591549 |
2015 |
|
rs869312756
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1801516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008).
|
25591549 |
2015 |
|
rs1801243
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008).
|
25591549 |
2015 |
|
rs732774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008).
|
25591549 |
2015 |
|
rs2273535
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest a model of dominant inheritance of ovarian cancer risk by the I31 allele of F31I and that the I31 allele may be a common ovarian cancer susceptibility allele of low penetrance.
|
15466974 |
2004 |
|
rs2240308
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied nine single nucleotide polymorphisms (SNPs) located in CTNNB1 (β-catenin) [rs4533622, rs2953], APC (rs11954856, rs351771, rs459552), and AXIN2 (rs4074947, rs7224837, rs3923087, rs2240308) in women with ovarian cancer without BRCA1/BRCA2 mutations (n = 228) and controls (n = 282).
|
24078348 |
2014 |