Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1042522
rs1042522
0.040 GeneticVariation BEFREE Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008). 25591549

2015

dbSNP: rs1042522
rs1042522
0.040 GeneticVariation BEFREE The rs1042522 polymorphism was not overall associated with o</span>varian cancer risk. 25060098

2014

dbSNP: rs1042522
rs1042522
0.040 GeneticVariation BEFREE In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian cancer risk than rs1042522 in TP53. 23192612

2013

dbSNP: rs1042522
rs1042522
0.040 GeneticVariation BEFREE Meta-analysis shows significant association of the TP53 Arg72Pro with ovarian cancer risk. 21952824

2012

dbSNP: rs1131691014
rs1131691014
0.020 GeneticVariation BEFREE Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008). 25591549

2015

dbSNP: rs878854066
rs878854066
0.020 GeneticVariation BEFREE Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008). 25591549

2015

dbSNP: rs1131691014
rs1131691014
0.020 GeneticVariation BEFREE Meta-analysis shows significant association of the TP53 Arg72Pro with ovarian cancer risk. 21952824

2012

dbSNP: rs878854066
rs878854066
0.020 GeneticVariation BEFREE Meta-analysis shows significant association of the TP53 Arg72Pro with ovarian cancer risk. 21952824

2012

dbSNP: rs876660754
rs876660754
0.010 GeneticVariation BEFREE A direct sequencing analysis of p53 revealed a p.V173M mutation in exon 5 in both the breast tumor and the ovarian cancer. 28662703

2017

dbSNP: rs1131691022
rs1131691022
0.010 GeneticVariation BEFREE As a proof of concept, we show that the combination of D269H/E195R, nutlin-3 and cisplatin induced massive apoptosis in ex vivo tissue slices of primary human ovarian cancers. 24136147

2013

dbSNP: rs1321845532
rs1321845532
0.010 GeneticVariation BEFREE As a proof of concept, we show that the combination of D269H/E195R, nutlin-3 and cisplatin induced massive apoptosis in ex vivo tissue slices of primary human ovarian cancers. 24136147

2013

dbSNP: rs2287497
rs2287497
0.010 GeneticVariation BEFREE In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian cancer risk than rs1042522 in TP53. 23192612

2013

dbSNP: rs2287498
rs2287498
0.010 GeneticVariation BEFREE In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian cancer risk than rs1042522 in TP53. 23192612

2013

dbSNP: rs121913343
rs121913343
0.010 GeneticVariation BEFREE We present the apparent BRCA1-related, although mutation negative, breast and ovarian cancer patient who subsequently was confirmed to be TP53 c.817C>T (p.R273C) mutation carrier and discuss the importance of peri-diagnostic oncogenetic TP53 testing in early breast cancer cases. 21535297

2011

dbSNP: rs397516436
rs397516436
0.010 GeneticVariation BEFREE High prevalence of codon 213Arg-->Stop mutations of the TP53 gene in human ovarian cancer in the southwestern part of The Netherlands. 9579562

1998