DisGeNET - a database of gene-disease associations

Attention deficit hyperactivity disorder, C1263846

Variant: rs2251214 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs2251214

SYT1

0.030

GeneticVariation

BEFREE

Additionally, in candidate gene studies the specific variant rs2251214 has been associated with attention-deficit/hyperactivity disorder (ADHD), antisocial personality disorder and other externalizing phenotypes in adults with ADHD, as well as with response to methylphenidate (MPH) treatment.

31059723

2019

dbSNP:

rs2251214

SYT1

0.030

GeneticVariation

BEFREE

Our findings suggest that SYT1-rs2251214 presents a broad influence in IR-MPH response variability in adults with ADHD, being involved with both symptom response and treatment persistence.

28461697

2018

dbSNP:

rs2251214

SYT1

0.030

GeneticVariation

BEFREE

We replicated a previously reported association between SYT1-rs2251214 and ADHD in adulthood.

28130000

2017