|
rs10223646
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs in tight linkage disequilibrium with the TSPYL1 rs10223646 SNP were significantly correlated with baseline severity of depression in patients with MDD in the Sequenced Treatment Alternatives to Relieve Depression and International SSRI Pharmacogenomics Consortium clinical trials.
|
31628858 |
2020 |
|
rs1333045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1333045 was associated with MDD in recessive model (OR (95% CI) = 2.221 (1.173-4.207), adjusted p value = 0.026).
|
31773399 |
2020 |
|
rs1333048
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analyses have shown that T A haplotype block (rs1333045 and rs1333048 respectively) significantly decreases risk of addiction, BP I, BP II, and MDD.
|
31773399 |
2020 |
|
rs1512325
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1512325 in NR3C2 gene and TSH concentration may be related to venlafaxine treatment outcome in Chinese Han MDD patients.
|
31757642 |
2020 |
|
rs1048220
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to determine the association of three BDNF variants (rs6265, rs1048218 and rs1048220) with Malaysian MDD patients.
|
30677092 |
2019 |
|
rs10914456
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>Conclusion.</i> This study suggests that, <i>Orx<sub>1</sub></i> rs10914456 and rs2271933 can be associated with MDD development.
|
30596528 |
2019 |
|
rs12649507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BHLHB2 rs2137947 for major depressive disorder and CLOCK rs12649507 for bipolar disorder were the most significant third loci in the three-locus combination model.
|
31323592 |
2019 |
|
rs135745
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TIMELESS rs4630333 and CSNK1E rs135745 were significantly associated with both major depressive disorder and bipolar disorder.
|
31323592 |
2019 |
|
rs1415125856
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After all, according to these findings, -1438A/G, 102T/C, and 5-HTTLPR polymorphisms could be considered as promising pharmacogenetic biomarkers in CIT/SERT treatment in major depressive disorder (MDD) patients to avoid the occurrence of SD.
|
31792367 |
2019 |
|
rs2032583
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MDD is associated with the rs2032582 (<i>G2677T</i>) and rs1128503 (<i>C1236T</i>) single-nucleotide polymorphisms (SNPs) of <i>ABCB1</i> but not with rs1045642, rs2032583, rs2235040, and rs2235015.
|
31333472 |
2019 |
|
rs2137947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BHLHB2 rs2137947 for major depressive disorder and CLOCK rs12649507 for bipolar disorder were the most significant third loci in the three-locus combination model.
|
31323592 |
2019 |
|
rs2235015
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MDD is associated with the rs2032582 (<i>G2677T</i>) and rs1128503 (<i>C1236T</i>) single-nucleotide polymorphisms (SNPs) of <i>ABCB1</i> but not with rs1045642, rs2032583, rs2235040, and rs2235015.
|
31333472 |
2019 |
|
rs2235040
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MDD is associated with the rs2032582 (<i>G2677T</i>) and rs1128503 (<i>C1236T</i>) single-nucleotide polymorphisms (SNPs) of <i>ABCB1</i> but not with rs1045642, rs2032583, rs2235040, and rs2235015.
|
31333472 |
2019 |
|
rs2271933
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>Conclusion.</i> This study suggests that, <i>Orx<sub>1</sub></i> rs10914456 and rs2271933 can be associated with MDD development.
|
30596528 |
2019 |
|
rs2470890
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the single-nucleotide polymorphism rs2470890 of CYP1A2 gene might be associated with treatment remission after VEN treatment in patients with MDD.
|
30875344 |
2019 |
|
rs2653349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no association was observed in <i>Orx<sub>2</sub></i> rs2653349 genotypes for MDD development (<i>p</i> > .05).
|
30596528 |
2019 |
|
rs33458
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous CC genotype of 3111T/C, GSK3B-AT/TT genotype of rs33458 and haplotype of TPH1 218A/C were associated with insomnia symptom of MDD.
|
31111219 |
2019 |
|
rs4630333
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TIMELESS rs4630333 and CSNK1E rs135745 were significantly associated with both major depressive disorder and bipolar disorder.
|
31323592 |
2019 |
|
rs6782011
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C G haplotype (rs6782011 and rs779867 respectively) was more prevalent among both BPD2 patients (OR (95%CI) = 2.03 (1.36-3.01), adjusted P value = 0.002) and MDD patients (OR (95%CI) = 2.08 (1.37-3.16), adjusted P value = 0.002) compared with controls.
|
31170425 |
2019 |
|
rs6921438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association was observed between VEGF-related SNP rs6921438 and subiculum atrophy in first-episode drug-naïve MDD patients.
|
30406404 |
2019 |
|
rs779867
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C G haplotype (rs6782011 and rs779867 respectively) was more prevalent among both BPD2 patients (OR (95%CI) = 2.03 (1.36-3.01), adjusted P value = 0.002) and MDD patients (OR (95%CI) = 2.08 (1.37-3.16), adjusted P value = 0.002) compared with controls.
|
31170425 |
2019 |
|
rs10457592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants from two previously unreported loci (rs10457592 on 6q16.2 and rs2004910 on 12q24.31) showed significant associations with MDD (P < 5 × 10<sup>-8</sup>) in a total of 336,753 subjects.
|
29728651 |
2018 |
|
rs11858956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analysis of results for 8,045,569 SNPs from a migraine GWAS (comprising 30,465 migraine cases and 143,147 control samples) and the top 10,000 SNPs from a MDD GWAS (comprising 75,607 MDD cases and 231,747 healthy controls), implicated three SNPs (rs146377178, rs672931, and rs11858956) with novel genome-wide significant association (P<sub>SNP</sub> ≤ 5 × 10<sup>-8</sup>) to migraine and MDD.
|
29995844 |
2018 |
|
rs1187352
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In 624 patients currently experiencing an MDE in the context of Major Depressive Disorder (MDD) (METADAP study), we assessed the association between 8 TRKB genetic polymorphisms (rs1778933, rs1187352, rs2289658, rs2289657, rs2289656, rs3824519, rs56142442 and rs1439050) and acute (previous month) or past (older than one month) SA.
|
30308049 |
2018 |
|
rs12476147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs12476147 (P=0.0078) was associated significantly with schizophrenia, but no SNPs showed statistically significant associations with major depressive disorder after Bonferroni correction.
|
29112096 |
2018 |