Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE In the current study, we examined BDNF polymorphisms (G-712A, C270T and Val66Met) in 202 patients with MD and 323 patients with schizophrenia. 21129438

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Significant interactions between the Val66Met polymorphism and 3 clinical characteristics - age at onset (p = 0.03), MDD duration (p = 0.04), and number of previous MDE (p = 0.04) - were evidenced for plasma BDNF levels. 28848102

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Serum BDNF levels, but not plasma levels of HVA or MHPG, and BDNF Val66Met polymorphism are related to the mirtazapine response in MDD. 22883353

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder. 16979146

2006

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response. 14582140

2003

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Effects of polymorphisms of serotonin transporter promoter (5-HTTLPR) and brain derived neurotrophic factor gene (G196A rs6265) on the risk of major depressive disorder in the Chinese Han population. 27212180

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF polymorphism was associated with atrophy of the PFC in MDD patients, which suggests that the BDNF Val66Met polymorphism may play an important role in the pathogenesis of early stages of MDD. 26078197

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder. 20167454

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE To determine the effect of BDNF gene val66met polymorphism on serum BDNF levels in drug-free patients with major depressive disorder (MDD) and healthy subjects, that differ by gender. 19589373

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The relationship was investigated between brain-derived neurotrophic factor (BDNF) concentrations, a <i>BDNF</i> polymorphism (196G>A), and the response to selective serotonin reuptake inhibitors (SSRIs) among Chinese patients with major depressive disorder (MDD). 31308724

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The current study looked at a population of patients with major depressive disorder (N = 107) to examine the association between the BDNF Val66Met polymorphism, resting state EEG alpha power, and depression severity. 23733090

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE To examine the effect of the BDNF Val66Met polymorphism on hippocampal and amygdala volumes in patients with major depression and in healthy control subjects. 17404118

2007

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The aim of our two-center study was to determine how the BDNF Val66Met</span> polymorphism and childhood adversity affect the volumetric measures of the hippocampus in healthy individuals and people with MDD. 23341118

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder. 25745134

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We investigated cross-sectionally in 1,435 individuals with lifetime MDD the impact of childhood abuse (CA) and recent life events on serum BDNF levels and assessed whether the impact of these events was moderated by the BDNF Val(66)Met polymorphism. 20703451

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The aim of this study was to determine which hippocampal dentate gyrus and cornu ammonis subfields are altered in MDD compared to healthy controls and which subfields are affected by the BDNF Val</span>66Met</span> polymorphism and child adversity. 25044977

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype. 22585743

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Our results do not support the hypothesis that the Val66Met promoter polymorphism in the BDNF gene influences the therapeutic response to mirtazapine in Korean MDD patients. 19493959

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We investigated the relationship between a brain-derived neurotrophic factor (BDNF) polymorphism (Val66Met) and the clinical response of patients with major depressive disorder to selective serotonin reuptake inhibitors (SSRIs; here, paroxetine and sertraline). 21338649

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The pattern of low BDNF and high inflammation in MDD may be influenced by the Val66Met polymorphism. 28656803

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE A functional polymorphism of the brain-derived neurotrophic factor, BDNF Val66Met, is associated with risk for major depression alongside impairments in memory and selective attention. 18721847

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We found no significant association of either the BDNF G196A or MTHFR C677T polymorphisms with major depressive disorder neither in female nor male group of patients. 23255668

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression and 171 age- and sex-similar control subjects. 16343697

2006

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Both clinical and pharmacological studies have implicated the common single nucleotide polymorphism (SNP) at position 196, Val66Met in the pathophysiology of major depressive disorder (MDD), and antidepressant response. 21188787

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide. 29432620

2018