Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE We have prospectively demonstrated the relationship between the single-nucleotide polymorphism of the Val158Met COMT gene (rs4680) and the hippocampal subfields in drug-naive MDD patients. 31239688

2019

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892

2019

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE We measured COMT gene methylation and polymorphisms (Val158Met) at the rs4468 locus in peripheral blood samples of healthy controls (n = 90) and patients with MDD (n = 90). 29723539

2018

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Together, our results indicate that the COMT Val158Met polymorphism is a vulnerability factor for MDD with distinct effects in different ethnic populations. 26803486

2016

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender. 26813412

2016

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene with MDD and BD. 25766270

2015

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE This study showed the involvement of A1298C, Val158Met and their interaction in MDD. 26021967

2015

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE An association was found between the Valine (Val) 108/158Methionine (Met) COMT polymorphism (rs4680) and major depressive disorder (MDD). 26253436

2015

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE rs4680 in COMT and rs3219151 in GABRA6 showed positive associations with PD and MDD. 25974322

2015

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE In several previous biochemical and genetic studies, the Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) and the C677T polymorphism of Methylenetetrahydrofolate reductase (MTHFR) have been suggested to be involved in the pathogenesis as well as the treatment response of major depressive disorder (MDD), but the results have been inconsistent. 24751310

2014

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression. 24555772

2014

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE DTI and genotyping for the COMT val158met gene (rs4680) polymorphism were conducted to determine the impact of COMT polymorphisms on white matter changes in patients with MDD. 23618651

2013

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Responses to venlafaxine treatment in major depressive disorder were stratified by COMT genotypes (Val158Met, rs4680) in a randomized, double-blind, placebo-controlled clinical trial. 23706899

2013

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). 21600957

2011

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The functional val108/158met polymorphism of the COMT gene (rs4680) was evaluated in major depressive disorder (MDD), and in the treatment response to antidepressants in MDD. 20071037

2010

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The val158met polymorphism of the COMT gene exemplifies the lack of consensus in the literature: although it is one of the most reported polymorphisms that relates to MDD vulnerability, its role is not corroborated by meta-analysis. 20558238

2010

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE This effect of rs4680 is similar to its observed influence on response to serotonergic and noradrenergic drug treatments in major depressive disorder. 19520435

2010

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE In the present study, the effect of COMT val158met on response to electroconvulsive therapy (ECT) was analyzed in a sample of 104 Caucasian patients (f = 71, m = 33) with pharmacologically treatment-resistant Major Depression. 19309019

2010

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Although several haplotype combinations showed significance, the combinations of G-T-G-G haplotype for rs6269, rs4633, rs4818 and rs4680 were only present in the MDD group (G-T 4.5%, corrected sim P=0.0001; G-T-G 3.87%, corrected sim P=0.001; G-T-G-G 3.3% corrected sim P=0.0025). 20531207

2010

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE COMT Val158met polymorphism was genotyped in 334 Chinese major depressive disorder (MDD) patients who were treated with fluoxetine for at least 4 weeks. 18533273

2009

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Dopamine 2 receptor gene (DRD2) polymorphism C957T (rs6277) and cathechol-o-methyltransferase (COMT) polymorphism Val158Met (rs4680) interaction was studied in 118 patients suffering from major depressive disorder (MDD) treated with ECT and 383 healthy controls. 18929622

2008

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotyped for the functional COMT val158met polymorphism and characterized for clinical response to antidepressive pharmacological treatment as measured by intra-individual changes of Hamilton Depression (HAM-D-21) scores over 6 weeks. 17522626

2008

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. 15583702

2005