Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE Our results suggest that CYP2D6 ultra-rapid metabolizer status contributes to venlafaxine-XR treatment remission in MDD patients; in particular, there is a PK-PD interaction with treatment remission associated with CYP2D6 URM phenotype and SLC6A4 5-HTTLPR L/L or SLC6A2 G1287A G/A genotype, respectively. 30578947

2019

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE Association between T-182C, G1287A polymorphism in NET gene and suicidality in major depressive disorder in Chinese patients. 29703117

2018

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE In conclusion, NET gene rs5569 polymorphism could increase the risk of MDD, especially among Asians. 30292339

2018

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE Relationship between G1287A of the NET Gene Polymorphisms and Brain Volume in Major Depressive Disorder: A Voxel-Based MRI Study. 26960194

2016

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE Different combinations of T-182C and the G1287A polymorphisms of NET gene might increase morbidity risk of M</span>D subpopulations. 26061302

2015

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE In the haplotype analysis, TAA (rs2242446-rs28386840-rs5569, from left to right) was associated with suicide attempts in MDD, although the significance (p=0.043) disappeared after Bonferroni correction. 24655776

2014

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE Our findings suggest that the NET T-182C and G1287A polymorphisms are not susceptibility factors for MDD. 23648227

2013

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed. 22727709

2012

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE To our knowledge, this is the first report showing that the G1287A polymorphism modifies rural residency as a risk factor for MDD. 19564048

2009

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE The present study suggests that the combined effect of rs2242446 and rs5569 in the NET gene could modify the response to the negative life events in triggering MD. 18779921

2008

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE We analyzed the NET promoter T-182C polymorphism and another silent polymorphism G1287A in exon 9 of the NET gene with a polymerase chain reaction (PCR)-based method in 216 patients with major depression and 210 unrelated, age-and sex-matched healthy control subjects. 17353941

2007

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE NET G1287A polymorphism appears not to be an important factor in susceptibility to MDD in a Japanese population. 17917281

2007

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE In a case control association study we investigated the newly identified T-182C polymorphism and an already known G1287A polymorphism in exon 9 of the NET gene in a sample of 193 patients with major depression and 136 healthy, non-related controls. 11927173

2002

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE One hundred and five patients with major depression and 74 unrelated matched controls were analyzed for a silent 1287G/A polymorphism (NET-8) in exon 9 of the NET gene. 10512149

1999