|
rs121909218
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Ectopic expressions of adenoviral (Ad)-wt-PTEN and -lipid phosphatase-deficient (G129E)-PTEN, but not both protein and -lipid phosphatase-deficient (C124S)-PTEN, reduced MMP-9 secretion and invasion by HA.
|
12414663 |
2002 |
|
rs121917887
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, the k-pn type proline-96 to serine (P96S) and neuroblastoma type serine-120 to glycine (S120G) mutations of Nm23-H1 abrogated its inhibitory activity on colonization and invasion.
|
12859952 |
2003 |
|
rs1442033697
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, overexpression of active wild-type PAI-1, but not P14-PAI-1 (T333R), in these cell lines showed reduced migration and invasion.
|
15149846 |
2004 |
|
rs121909218
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results indicate that the G129E mutant blocks invasion as efficiently as wild-type PTEN transfection.
|
15273733 |
2004 |
|
rs1194624468
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overexpression of FAK mutant (Y397F) could partially mimic the effect of PTEN on cell invasion.
|
15986432 |
2005 |
|
rs80358829
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The BRCA2 C5972T allele is a common variant in Poland that increases the risk of DCIS with micro-invasion.
|
16280055 |
2005 |
|
rs1799939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overexpression of G691S RET increased pancreatic cancer cell invasion.
|
16357163 |
2005 |
|
rs771086543
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We further showed that ARF6/extracellular signal-regulated kinase (ERK) signaling is required for the EFA6A-mediated cell invasion because both EFA6A(E242K) and ARF6 dominant negative mutant ARF6(T27N) markedly reduced the phosphorylated ERK level and EFA6A-mediated invasive capacity.
|
16452216 |
2006 |
|
rs772903705
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We further showed that ARF6/extracellular signal-regulated kinase (ERK) signaling is required for the EFA6A-mediated cell invasion because both EFA6A(E242K) and ARF6 dominant negative mutant ARF6(T27N) markedly reduced the phosphorylated ERK level and EFA6A-mediated invasive capacity.
|
16452216 |
2006 |
|
rs104894403
|
|
|
0.010 |
GeneticVariation |
BEFREE |
All three Cx26 variants also altered the distribution of filamentous actin and significantly reduced cell migration, while only the D66H mutant failed to inhibit cell invasion through matrigel.
|
16777986 |
2006 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway.
|
16960555 |
2007 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway.
|
16960555 |
2007 |
|
rs1418810723
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway.
|
16960555 |
2007 |
|
rs587782359
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Assessment of the P373L mutation effect was based on cell aggregation and invasion assays.
|
17434710 |
2007 |
|
rs2227983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A marked decrease on EGFR phosphorylation (P < 0.01) and c-Myc activation (P = 0.02) was observed in patients with R497K polymorphism, which is associated with decreased invasion (P = 0.01), lower nodal involvement (P = 0.02), reduced subsequent metastasis (P < 0.01), and longer disease-free (P < 0.01) as well as overall (P < 0.01) survival in stage II/III colorectal carcinoma patients who had received curative surgery.
|
17575224 |
2007 |
|
rs80338948
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also demonstrate that cells expressing (R143W)Cx26 are significantly less susceptible to cellular invasion by the enteric pathogen Shigella flexneri than (WT)Cx26-expressing cells.
|
17581693 |
2007 |
|
rs28934576
|
|
|
0.030 |
GeneticVariation |
BEFREE |
R273H expression in p53-null cancer cell SK-OV-3 and Saos-2 did not significantly affect cell invasion and migration activities.
|
17636407 |
2007 |
|
rs1451539938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the DN effect on tumor migration and invasion, we generated cells that stably co-expressed wild-type (wt) and R273H DN mutant TP53 (273H cells), and wt and R213Q recessive mutant TP53 (213Q cells), by transfection in endometrial cancer cells HHUA that expressed wt p53.
|
17636407 |
2007 |
|
rs587778720
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the DN effect on tumor migration and invasion, we generated cells that stably co-expressed wild-type (wt) and R273H DN mutant TP53 (273H cells), and wt and R213Q recessive mutant TP53 (213Q cells), by transfection in endometrial cancer cells HHUA that expressed wt p53.
|
17636407 |
2007 |
|
rs121917887
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Mutational analysis of Nm23-H1 revealed that substitution mutants P96S and S120G did not inhibit motility and invasion.
|
17671192 |
2007 |
|
rs1022088103
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutational analysis of Nm23-H1 revealed that substitution mutants P96S and S120G did not inhibit motility and invasion.
|
17671192 |
2007 |
|
rs1231584616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutational analysis of Nm23-H1 revealed that substitution mutants P96S and S120G did not inhibit motility and invasion.
|
17671192 |
2007 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V600E was associated with extrathyroidal invasion (P < 0.0001), multicentricity (P = 0.0026), presence of nodal metastases (P = 0.0009), class III vs. classes I and II (P < 0.00000006), and absence of tumor capsule (P < 0.0001), in particular in follicular- and micro-PTC variants.
|
17785355 |
2007 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V600E was associated with extrathyroidal invasion (P < 0.0001), multicentricity (P = 0.0026), presence of nodal metastases (P = 0.0009), class III vs. classes I and II (P < 0.00000006), and absence of tumor capsule (P < 0.0001), in particular in follicular- and micro-PTC variants.
|
17785355 |
2007 |
|
rs1049074086
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D.
|
17875703 |
2007 |