|
rs376066276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, our study demonstrates that the R64Q mutation abolishes the suppressive effects of TRIM21 on the invasion of breast cancer cells.
|
31622717 |
2020 |
|
rs772893086
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study demonstrates that IDH1 R132H mutation with increased oncometabolite R-2HG in PCa cells may play important roles to increase PCa cell invasion.
|
31846689 |
2020 |
|
rs1046282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs11064
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It also showed that SNP rs11064 was associated with advanced FIGO stage (P = 0.001), deep myometrial invasion (P = 0.047), and lymph node metastasis (P = 0.048) under the codominant model in ECs.
|
31043860 |
2019 |
|
rs11801299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RB patients carrying AA genotype and A allele at rs11801299 were more likely to have tumor invasion and poor differentiation.
|
30597480 |
2019 |
|
rs1194338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Female patients and patients with a smoking habit who carried the CA + AA genotype of rs1194338 had a lower risk of developing vascular invasion (p = 0.049) and a high Child-Pugh grade (B or C) (p = 0.036), respectively.
|
31500187 |
2019 |
|
rs121913412
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results revealed that a lower dose of sorafenib was able to inhibit cell viability, migration, and invasion of wild-type and T41A-mutated DTs.
|
30980399 |
2019 |
|
rs145204276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results shown that patients who carries genotype ins/del or del/del at SNP rs145204276 showed decreased risk of pathological lymph node metastasis disease (OR=0.545, p=0.043) and risk of seminal vesicle invasion (OR=0.632, p=0.022) comparing to with genotype ins/ins.
|
31673232 |
2019 |
|
rs1800625
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analysis revealed that among UCC patients aged younger than 65 years, those with a C allele at rs1800625 had a higher incidence of muscle invasive tumor and lymph node invasion.
|
30824390 |
2019 |
|
rs2070744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, cervical cancer patients with genotypes TC/CC in eNOS SNP rs2070744 carried less risk of advanced stage [odds ratios (OR) = 0.30, 95% confidence interval (CI)=0.09-0.97, <i>p</i>=0.036], parametrium invasion (OR=0.16, 95% CI=0.02-0.75, <i>p</i>=0.009) and pelvic lymph node metastasis (OR=0.12, 95% CI=0.01-0.89, <i>p</i>=0.016).
|
31258766 |
2019 |
|
rs3212948
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs371769427
|
|
|
0.010 |
GeneticVariation |
BEFREE |
U2AF1 S34F induced expression of genes involved in the epithelial-mesenchymal transition (EMT) and increased tumor cell invasion.
|
31836708 |
2019 |
|
rs3741219
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, cervical cancer patients with AA/AG in rs3741219 also had less risk to develop pelvic lymph node metastasis (OR: 0.17, 95% CI: 0.05-0.63, <i>p</i>=0.008), large tumor (OR: 0.17, 95% CI: 0.04-0.82, <i>p</i>=0.014) as well as parametrium (OR: 0.26, 95% CI: 0.07-0.95, <i>p</i>=0.045) and vagina invasion (OR: 0.25, 95% CI: 0.07-0.91, <i>p</i>=0.041, as compared to those with GG.
|
31772651 |
2019 |
|
rs3829078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, patients with CaP with an initial PSA level ≤10 ng/ml who carried at least one G allele at CA9 rs3829078 had a 4.532-fold and 3.484-fold risk of lymph node metastasis and lymphovascular invasion, respectively.
|
31155437 |
2019 |
|
rs387906698
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It showed that migration and invasion were significantly increased in R116C-bearing PANC-1 cells compared with wild type counterparts.
|
31521106 |
2019 |
|
rs4024
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs735482
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs737241
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs738791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although CT/TT genotype of MMP-11 gene rs738791 tended to increase the risk of developing stage II disease at least (p=0.035; OR: 2.16, 95% CI: 1.05-4.44) and deep stromal invasion more than 10 mm (p=0.043; OR: 2.08, 95% CI: 1.02-4.26) with CC as a reference in patients with uterine cervical cancer.
|
31337950 |
2019 |
|
rs1057519788
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Combination of Twist1 siRNA and crizotinib significantly reduced cell vitality, inhibited cell invasion and migration, and promoted apoptosis in A549-CD74-ROS1 G2032R mutation cells.
|
29477381 |
2018 |
|
rs12918952
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cervical cancer patients with GA/AA in rs12918952 tend to have more risk to develop parametrium invasion and pelvic lymph node metastasis.
|
30013442 |
2018 |
|
rs1431090090
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functionally, GATA3-acetylation mimics K119Q mutant was found to inhibit lung adenocarcinoma cell migration and invasion with concomitant downregulation of EMT-controlling transcriptional factors Slug, Zeb1 and Zeb2.
|
29453984 |
2018 |
|
rs1646724
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further investigation revealed that rs1646724 may affect expression of SLC35B4, which encodes a glycosyltransferase, and that down-regulation of SLC35B4 by transfecting short hairpin RNA in DU145 human prostate cancer cell suppressed proliferation, migration and invasion.
|
29682886 |
2018 |
|
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
With the subgroup of EGFR L858R mutation, variant genotypes (GT + TT) of <i>eNOS</i> 894 G/T were significantly associated with lymph node invasion.
|
30026850 |
2018 |
|
rs1800624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, cervical cancer patients with genotypes TA/AA in rs1800624 exhibited a lower risk of parametrium invasion, moderate-to-poor cell differentiation, and pelvic lymph node metastasis.
|
30410591 |
2018 |